KMT5A, lysine methyltransferase 5A, 387893

N. diseases: 49; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 AlteredExpression phenotype BEFREE We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets. 25256401 2014
CUI: C0024305
Disease: Lymphoma, Non-Hodgkin
Lymphoma, Non-Hodgkin 		0.010 GeneticVariation disease BEFREE Prognostic value of microRNA 502 binding site SNP in the 3'-untranslated region of the SET8 gene in patients with non-Hodgkin's lymphoma. 25343552 2014
CUI: C0220605
Disease: Adult Non-Hodgkin Lymphoma
Adult Non-Hodgkin Lymphoma 		0.010 GeneticVariation disease BEFREE Prognostic value of microRNA 502 binding site SNP in the 3'-untranslated region of the SET8 gene in patients with non-Hodgkin's lymphoma. 25343552 2014
CUI: C0220612
Disease: Childhood Non-Hodgkin Lymphoma
Childhood Non-Hodgkin Lymphoma 		0.010 GeneticVariation disease BEFREE Prognostic value of microRNA 502 binding site SNP in the 3'-untranslated region of the SET8 gene in patients with non-Hodgkin's lymphoma. 25343552 2014
CUI: C4721532
Disease: Lymphoma, Non-Hodgkin, Familial
Lymphoma, Non-Hodgkin, Familial 		0.010 GeneticVariation disease BEFREE Prognostic value of microRNA 502 binding site SNP in the 3'-untranslated region of the SET8 gene in patients with non-Hodgkin's lymphoma. 25343552 2014
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 AlteredExpression disease BEFREE SET8 expression is associated with overall survival in gastric cancer. 26634528 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 AlteredExpression disease BEFREE SET8 expression is associated with overall survival in gastric cancer. 26634528 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 AlteredExpression phenotype BEFREE SETD8 was identified as a direct target of miR-127-3p, and SETD8 expression decreased post miR-127-3p overexpression, while SETD8 overexpression could reverse the potential influence of miR-127-3p on the migration and invasion of OS cells. 26707641 2016
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.030 Biomarker disease BEFREE MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells. 26707641 2016
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.030 Biomarker disease BEFREE MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells. 26707641 2016
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.030 Biomarker disease BEFREE MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells. 26707641 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.080 Biomarker group BEFREE Mounting evidence suggested that histone H4K20-specific methyltransferase SET8 is required to maintain the malignant phenotype of various cancer types; however, the role of SET8 in mediating tumor metastasis in prostate cancer (PCa) has remained elusive. 26717907 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.060 AlteredExpression phenotype BEFREE Luciferase reporter assays suggested that E-cadherin and vimentin are direct targets of SET8; furthermore, loss- and gain-of function studies of SET8 and ZEB1 indicated that suppression of downstream E-cadherin and activation of vimentin are important mechanisms by which SET8 and ZEB1 cooperatively trigger metastasis. 26717907 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 Biomarker group BEFREE Mounting evidence suggested that histone H4K20-specific methyltransferase SET8 is required to maintain the malignant phenotype of various cancer types; however, the role of SET8 in mediating tumor metastasis in prostate cancer (PCa) has remained elusive. 26717907 2016
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.030 Biomarker disease BEFREE Furthermore, SET8 was shown to be physically associated with the epithelial-mesenchymal transition (EMT) inducer zinc finger E-box-binding homeobox 1 (ZEB1) in PCa cell lines. 26717907 2016
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.030 Biomarker disease BEFREE Furthermore, SET8 was shown to be physically associated with the epithelial-mesenchymal transition (EMT) inducer zinc finger E-box-binding homeobox 1 (ZEB1) in PCa cell lines. 26717907 2016
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 Biomarker group BEFREE Mounting evidence suggested that histone H4K20-specific methyltransferase SET8 is required to maintain the malignant phenotype of various cancer types; however, the role of SET8 in mediating tumor metastasis in prostate cancer (PCa) has remained elusive. 26717907 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.080 AlteredExpression disease BEFREE Furthermore, high expression of SET8 was significantly associated with poor overall survival (OS) and disease free survival (DFS) of breast cancer. 27080302 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.080 Biomarker group BEFREE Thus, the miR-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of cancer and a focal point for possible therapeutic intervention. 27080302 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE Furthermore, high expression of SET8 was significantly associated with poor overall survival (OS) and disease free survival (DFS) of breast cancer. 27080302 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 Biomarker group BEFREE Thus, the miR-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of cancer and a focal point for possible therapeutic intervention. 27080302 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.080 AlteredExpression disease BEFREE To further elucidate the prognostic relevance of this SNP in breast cancer, we conducted a clinical study as well as SET8 expression analysis in a cohort of 1,190 breast cancer patients. 27144429 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.080 GeneticVariation group BEFREE A single-nucleotide polymorphism (SNP) locus rs16917496 (T > C) within the 3'-untranslated region (3'-UTR) of SET8 was associated with susceptibility in several malignancies including breast cancer. 27144429 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE To further elucidate the prognostic relevance of this SNP in breast cancer, we conducted a clinical study as well as SET8 expression analysis in a cohort of 1,190 breast cancer patients. 27144429 2016
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 AlteredExpression group BEFREE SET8 expression was significantly higher in breast tumor tissue than in paired adjacent normal tissue. 27144429 2016