LIN28B, lin-28 homolog B, 389421

N. diseases: 126; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.900 Biomarker disease MGD
CUI: C0027766
Disease: Nervous System Neoplasms
Nervous System Neoplasms 		0.100 Biomarker group HPO
CUI: C0241577
Disease: Elevated urinary catecholamines
Elevated urinary catecholamines 		0.100 Biomarker phenotype HPO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 AlteredExpression group BEFREE Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation. 16971064 2006
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE These findings strongly implicate a critical role of LIN28B during development and tumorigenesis and suggest a possible novel mechanism. 16971064 2006
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation. 16971064 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 AlteredExpression disease BEFREE Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. 16971064 2006
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Identification of ten loci associated with height highlights new biological pathways in human growth. 18391950 2008
CUI: C0489786
Disease: Height
Height 		0.100 GeneticVariation phenotype GWASDB Identification of ten loci associated with height highlights new biological pathways in human growth. 18391950 2008
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Many sequence variants affecting diversity of adult human height. 18391951 2008
CUI: C0489786
Disease: Height
Height 		0.100 GeneticVariation phenotype GWASDB Many sequence variants affecting diversity of adult human height. 18391951 2008
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASDB Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. 19448620 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. 19448621 2009
CUI: C1629609
Disease: Age at menopause
Age at menopause 		0.100 GeneticVariation phenotype GWASDB Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. 19448621 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. 19448622 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. 19448622 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASCAT Genetic variation in LIN28B is associated with the timing of puberty. 19448623 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASDB Genetic variation in LIN28B is associated with the timing of puberty. 19448623 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.400 AlteredExpression group BEFREE To further understand the role of lin-28 in cancer, we analysed the expression of lin-28 and its homologue lin-28B in tumour samples, and evaluated their associations with let-7a maturation, IGF-II expression, disease features and outcomes in 211 patients with primary epithelial ovarian cancer. 19477633 2009
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.070 AlteredExpression disease BEFREE To further understand the role of lin-28 in cancer, we analysed the expression of lin-28 and its homologue lin-28B in tumour samples, and evaluated their associations with let-7a maturation, IGF-II expression, disease features and outcomes in 211 patients with primary epithelial ovarian cancer. 19477633 2009
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.050 AlteredExpression disease BEFREE To further understand the role of lin-28 in cancer, we analysed the expression of lin-28 and its homologue lin-28B in tumour samples, and evaluated their associations with let-7a maturation, IGF-II expression, disease features and outcomes in 211 patients with primary epithelial ovarian cancer. 19477633 2009
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 Biomarker group CTD_human Our work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis. 19483683 2009
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 AlteredExpression group BEFREE Here we show that LIN28 and LIN28B are overexpressed in primary human tumors and human cancer cell lines (overall frequency approximately 15%), and that overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets. 19483683 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.400 Biomarker group CTD_human LIN28 and LIN28b facilitate cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types. 19483683 2009
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Biomarker phenotype CTD_human Lin28 promotes transformation and is associated with advanced human malignancies. 19483683 2009