LIN28B, lin-28 homolog B, 389421

N. diseases: 126; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.900 Biomarker disease MGD
CUI: C0027766
Disease: Nervous System Neoplasms
Nervous System Neoplasms 		0.100 Biomarker group HPO
CUI: C0241577
Disease: Elevated urinary catecholamines
Elevated urinary catecholamines 		0.100 Biomarker phenotype HPO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 AlteredExpression group BEFREE Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation. 16971064 2006
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE These findings strongly implicate a critical role of LIN28B during development and tumorigenesis and suggest a possible novel mechanism. 16971064 2006
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation. 16971064 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 AlteredExpression disease BEFREE Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. 16971064 2006
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Many sequence variants affecting diversity of adult human height. 18391951 2008
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Identification of ten loci associated with height highlights new biological pathways in human growth. 18391950 2008
CUI: C0489786
Disease: Height
Height 		0.100 GeneticVariation phenotype GWASDB Identification of ten loci associated with height highlights new biological pathways in human growth. 18391950 2008
CUI: C0489786
Disease: Height
Height 		0.100 GeneticVariation phenotype GWASDB Many sequence variants affecting diversity of adult human height. 18391951 2008
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 Biomarker group CTD_human Our work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis. 19483683 2009
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 AlteredExpression group BEFREE Here we show that LIN28 and LIN28B are overexpressed in primary human tumors and human cancer cell lines (overall frequency approximately 15%), and that overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets. 19483683 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.400 Biomarker group CTD_human LIN28 and LIN28b facilitate cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types. 19483683 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.400 AlteredExpression group BEFREE To further understand the role of lin-28 in cancer, we analysed the expression of lin-28 and its homologue lin-28B in tumour samples, and evaluated their associations with let-7a maturation, IGF-II expression, disease features and outcomes in 211 patients with primary epithelial ovarian cancer. 19477633 2009
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Biomarker phenotype CTD_human Lin28 promotes transformation and is associated with advanced human malignancies. 19483683 2009
CUI: C0086692
Disease: Benign Neoplasm
Benign Neoplasm 		0.300 Biomarker group CTD_human Lin28 promotes transformation and is associated with advanced human malignancies. 19483683 2009
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE Here we show that LIN28 and LIN28B are overexpressed in primary human tumors and human cancer cell lines (overall frequency approximately 15%), and that overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets. 19483683 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. 19448622 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASCAT Genetic variation in LIN28B is associated with the timing of puberty. 19448623 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASDB Genetic variation in LIN28B is associated with the timing of puberty. 19448623 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. 19448622 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. 19448621 2009
CUI: C1314691
Disease: Age at menarche
Age at menarche 		0.100 GeneticVariation phenotype GWASDB Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. 19448620 2009
CUI: C1629609
Disease: Age at menopause
Age at menopause 		0.100 GeneticVariation phenotype GWASDB Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. 19448621 2009