|
Neuroblastoma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms.
|
31601998 |
2020 |
|
Neuroblastoma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
By this study, a regulatory loop is proposed, wherein, ODC silencing in Y79 cells to result in decreased polyamine levels, thereby, leading to altered protein levels of Lin28b, MMP-2 and MMP-9, which falls in line with earlier studies in neuroblastoma.
|
29241071 |
2018 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We also found that the combination of polymorphisms in CASC15, LIN28B, and LMO1 may be used to predict neuroblastoma risk (AUC=0.63, 95% CI=0.59-0.67).
|
29024823 |
2017 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
GWASCAT |
Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.
|
28545128 |
2017 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
With the purpose to evaluate the association between LIN28B gene polymorphisms and neuroblastoma susceptibility in Southern Chinese population, we conducted this study with 256 neuroblastoma cases and 531 cancer-free controls.
|
27021521 |
2016 |
|
Neuroblastoma
|
0.900 |
Biomarker
|
disease |
BEFREE |
Here we show, however, that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7.
|
27383785 |
2016 |
|
Neuroblastoma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms.
|
26123663 |
2015 |
|
Neuroblastoma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
In vitro experiments using NB cell lines, BE(2)-C, SMS-KCNR, and CHLA90 show that DFMO treatment reduced LIN28B and MYCN protein levels and increased Let-7 miRNA and decreased neurosphere formation.
|
25415050 |
2015 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability.
|
25312269 |
2014 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals.
|
23222812 |
2013 |
|
Neuroblastoma
|
0.900 |
Biomarker
|
disease |
CTD_human |
Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.
|
22941191 |
2012 |
|
Neuroblastoma
|
0.900 |
SusceptibilityMutation
|
disease |
ORPHANET |
The relationship between hygiene and microbial burden in atopic dermatitis risk based on a systematic review.
|
22911191 |
2012 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.
|
22941191 |
2012 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
GWASCAT |
Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.
|
22941191 |
2012 |
|
Neuroblastoma
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression.
|
23042116 |
2012 |
|
Neuroblastoma
|
0.900 |
Biomarker
|
disease |
CTD_human |
These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression.
|
23042116 |
2012 |
|
Neuroblastoma
|
0.900 |
GeneticVariation
|
disease |
GWASDB |
Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.
|
22941191 |
2012 |
|
Neuroblastoma
|
0.900 |
Biomarker
|
disease |
MGD |
|
|
|
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Using LIN28B-expressing cancer cell lines, we found that the rate of extracellular acidification, glucose uptake, and lactate secretion are all suppressed by LIN28B knockdown in vitro and in vivo.
|
30742065 |
2019 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Lin28A and Lin28B possess significant prognostic values in various human malignancies.
|
30976203 |
2019 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Analysis of LIN28B and HMGA2 expression levels in cohorts from The Cancer Genome Atlas sarcoma dataset revealed a strong inverse-relationship between elevated expression and overall survival (OS) in 260 patients (p = 0.005) and disease-free survival (DFS) in 231 patients (p = 0.02), suggesting LIN28B and HMGA2 are important regulators of sarcoma biology.
|
31147574 |
2019 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Considering the similarities between cancer and trophoblast cells, we hypothesize that LIN28B also is necessary for the presence of AR in human trophoblast cells.
|
31215730 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis.
|
30742065 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Notably, downregulation of RPSAP52 impairs the balance between the oncogene LIN28B and the tumor suppressor let-7 family of miRNAs, inhibits cellular proliferation and migration in vitro and slows down tumor growth in vivo.
|
31484926 |
2019 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer.
|
29503447 |
2018 |