|
Nephrotic Syndrome
|
0.310 |
GeneticVariation
|
group |
BEFREE |
In three families, in whom mutations in known NS genes were excluded, but in whom a recessive, monogenic cause of NS was strongly suspected based on pedigree information, we identified homozygous variants of unknown significance (VUS) in the gene LAMA5.
|
29534211 |
2019 |
|
Colorectal Carcinoma
|
0.140 |
Biomarker
|
disease |
BEFREE |
Half of the Caucasian-identified variants, including the recently fine-mapped BMP pathway loci, BMP4, GREM1, BMP2 and LAMA 5, did not show any evidence for association with CRC in SCH (OR ~1; p-value >0.1).
|
22879968 |
2012 |
|
Colorectal Carcinoma
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
BCAM and LAMA5 were identified as molecular targets within both tumor cells and TME of KRAS-mutant hepatic metastasis from colorectal cancer, where they were specifically overexpressed.
|
27143691 |
2016 |
|
Colorectal Carcinoma
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
We found that two of the loci most strongly linked with colorectal cancer (CRC) risk, 8q24 (upstream of MYC) and 18q21 (in the intron of SMAD7), as well as 20q13 (in the intron of LAMA5), are tightly associated with the prognosis of rectal cancer patients.
|
29119627 |
2018 |
|
Colorectal Carcinoma
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Notably, two independent meta-analyses of genome-wide association studies found the C-allele of LAMA5 rs4925386-C/T correlated with the risk of colorectal cancer.
|
26968355 |
2016 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study, for the first time, indicates a prominent role for laminin α4 in ASM function and in inflammation, AHR, and remodeling in asthma, whereas the role of laminin α5 is more subtle.
|
31553662 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The laminin alpha 5 gene (<i>LAMA5</i>) plays a master role in the maintenance and function of the extracellular matrix (ECM) in mammalian tissues, which is critical in developmental patterning, stem cell niches, cancer and genetic diseases.
|
28735299 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.
|
26968355 |
2016 |
|
Hematuria
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Mice with a hypomorphic mutation in the orthologous gene Lama5 develop proteinuria and hematuria.
|
29534211 |
2019 |
|
Hematuria
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
This is the third report linking a LAMA5 variant with human renal disease and expanding the spectrum of genes involved in glomerular pathologies accompanied by familial hematurias.
|
29764427 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Here we show that the preferential binding of Lu/B-CAM to laminin α5 promotes tumor cell migration.
|
24036115 |
2013 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Lutheran/basal cell adhesion molecule (Lu/BCAM) promotes tumor cell migration by binding to laminin α5 chain, a subunit of laminins 511 and 521.
|
31413112 |
2019 |
|
Kidney Failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, mutation of a fifth (Lama5) gene in podocytes in mice causes proteinuria, nephrotic syndrome, and progression to renal failure.
|
21327778 |
2011 |
|
Kidney Failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, laminin α5 mutation in podocytes leads to proteinuria and renal failure in mice.
|
22683419 |
2012 |
|
Secondary malignant neoplasm of liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
LAMA5 is required for the successful growth of hepatic metastases where it promotes branching angiogenesis and modulates Notch signalling.
|
31064120 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
BCAM and LAMA5 were identified as molecular targets within both tumor cells and TME of KRAS-mutant hepatic metastasis from colorectal cancer, where they were specifically overexpressed.
|
27143691 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.
|
26968355 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The laminin alpha 5 gene (<i>LAMA5</i>) plays a master role in the maintenance and function of the extracellular matrix (ECM) in mammalian tissues, which is critical in developmental patterning, stem cell niches, cancer and genetic diseases.
|
28735299 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
BCAM and LAMA5 were identified as molecular targets within both tumor cells and TME of KRAS-mutant hepatic metastasis from colorectal cancer, where they were specifically overexpressed.
|
27143691 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Notably, two independent meta-analyses of genome-wide association studies found the C-allele of LAMA5 rs4925386-C/T correlated with the risk of colorectal cancer.
|
26968355 |
2016 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of human breast cancer cases revealed reduced survival in cases where α3 integrin and LAMA5 are both overexpressed.
|
24002891 |
2014 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Despite lama5 being a known attachment site for GBM, lama5 expression had no effect on U251MG association with blood vessels.
|
30389143 |
2018 |
|
Focal glomerulosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in COL4A5 cause classical X-linked Alport Syndrome, while rare mutations in the LAMA5 have been reported in patients with focal segmental glomerulosclerosis.
|
29764427 |
2018 |
|
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This is the third report linking a LAMA5 variant with human renal disease and expanding the spectrum of genes involved in glomerular pathologies accompanied by familial hematurias.
|
29764427 |
2018 |
|
Mucopolysaccharidoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collagen IV and laminin α-5 (p = 0.002, 0.0004) staining demonstrated increased ECM deposition within the reticular and capillary network of MPS samples.
|
30226843 |
2018 |