Anti-Glomerular Basement Membrane Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Maternal alloimmune IgG causes anti-glomerular basement membrane disease in perinatal transgenic mice that express human laminin α5.
|
31530475 |
2019 |
Posterior Vitreous Detachment
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Early posterior vitreous detachment is associated with LAMA5 dominant mutation.
|
30589377 |
2019 |
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke and that inhibiting its signaling may have a neuroprotective effect.
|
30777135 |
2019 |
Tumor Angiogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of Laminin 511 was associated with reduced survival in several independent colorectal cancer cohorts and angiogenesis signatures or vessel density significantly correlated with LAMA5 expression.
|
31064120 |
2019 |
Tumour inflammation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This data demonstrates a mechanism whereby tumour inflammation induces LAMA5 expression in colorectal cancer cells.
|
31064120 |
2019 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Despite lama5 being a known attachment site for GBM, lama5 expression had no effect on U251MG association with blood vessels.
|
30389143 |
2018 |
Focal glomerulosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in COL4A5 cause classical X-linked Alport Syndrome, while rare mutations in the LAMA5 have been reported in patients with focal segmental glomerulosclerosis.
|
29764427 |
2018 |
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This is the third report linking a LAMA5 variant with human renal disease and expanding the spectrum of genes involved in glomerular pathologies accompanied by familial hematurias.
|
29764427 |
2018 |
Mucopolysaccharidoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collagen IV and laminin α-5 (p = 0.002, 0.0004) staining demonstrated increased ECM deposition within the reticular and capillary network of MPS samples.
|
30226843 |
2018 |
Multiple Myeloma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among them, the expression of ST3GAL6-AS1, LAMA5-AS1and RP11-175D17.3wereassociated with stage and risk status of MM.
|
29459023 |
2018 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantification of glioblastoma progression in zebrafish xenografts: Adhesion to laminin alpha 5 promotes glioblastoma microtumor formation and inhibits cell invasion.
|
30389143 |
2018 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantification of glioblastoma progression in zebrafish xenografts: Adhesion to laminin alpha 5 promotes glioblastoma microtumor formation and inhibits cell invasion.
|
30389143 |
2018 |
Myasthenic Syndromes, Congenital
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A presynaptic congenital myasthenic syndrome attributed to a homozygous sequence variant in LAMA5.
|
29377152 |
2018 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Lama5 has been implicated in cancer cell survival, proliferation and invasion and is a known adhesion site for GBM cells.
|
30389143 |
2018 |
Alport Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
A modifier role of LAMA5 on the background of a hypomorphic Alport syndrome causing mutation is a possible explanation of our findings.
|
29764427 |
2018 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Despite lama5 being a known attachment site for GBM, lama5 expression had no effect on U251MG association with blood vessels.
|
30389143 |
2018 |
Renal cyst
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The cystic phenotype overlaps with that of a mouse model, which carried a Lama5 hypomorphic mutation that caused severely reduced Lama5 protein levels and produced kidney cysts.
|
29764427 |
2018 |
Myopia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Presynaptic congenital myasthenic syndrome with a homozygous sequence variant in LAMA5 combines myopia, facial tics, and failure of neuromuscular transmission.
|
28544784 |
2017 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer.
|
27143691 |
2016 |
Hypospadias
|
0.010 |
Biomarker
|
disease |
BEFREE |
Perturbation of LAMA5, and possibly other basement membrane components, may cause hypospadias in humans.
|
27208857 |
2016 |
Penile hypospadias
|
0.010 |
Biomarker
|
disease |
BEFREE |
Perturbation of LAMA5, and possibly other basement membrane components, may cause hypospadias in humans.
|
27208857 |
2016 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of human breast cancer cases revealed reduced survival in cases where α3 integrin and LAMA5 are both overexpressed.
|
24002891 |
2014 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of human breast cancer cases revealed reduced survival in cases where α3 integrin and LAMA5 are both overexpressed.
|
24002891 |
2014 |
Galloway Mowat syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a cohort of 18 patients with GMS or a GMS-like phenotype we therefore analyzed the genes encoding laminin beta2 (LAMB2), laminin alpha5 (LAMA5), alpha3-integrin (ITGA3), beta1-integrin (ITGB1) and alpha-actinin-4 (ACTN4), but we failed to find causative mutations in these genes.
|
18594871 |
2008 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
In HCC cell lines, laminin alpha 5 heterotrimerized with beta and gamma chains and was secreted into the culture media.
|
18635166 |
2008 |