|
Cystic kidney
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Short stature
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Familial hematuria
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.
|
14691145 |
2003 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
LHGDN |
Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics.
|
16179086 |
2005 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.
|
15967115 |
2005 |
|
Polycystic Kidney, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
LHGDN |
Laminin 5 regulates polycystic kidney cell proliferation and cyst formation.
|
16870608 |
2006 |
|
Infection
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Keratinocyte-secreted laminin 5 can function as a transient receptor for human papillomaviruses by binding virions and transferring them to adjacent cells.
|
16940506 |
2006 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin.
|
17888902 |
2007 |
|
Polycythemia Vera
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adhesion was inhibited when PV RBCs were incubated with anti-Lutheran blood group/basal cell adhesion molecule (Lu/BCAM) or when HUVECs were treated with anti-laminin alpha(5) and to a lesser extent with anti-alpha(3) integrin.
|
17412890 |
2007 |
|
Junctional Epidermolysis Bullosa
|
0.010 |
Biomarker
|
disease |
LHGDN |
Biological function of laminin-5 and pathogenic impact of its deficiency.
|
17000025 |
2007 |
|
Galloway Mowat syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a cohort of 18 patients with GMS or a GMS-like phenotype we therefore analyzed the genes encoding laminin beta2 (LAMB2), laminin alpha5 (LAMA5), alpha3-integrin (ITGA3), beta1-integrin (ITGB1) and alpha-actinin-4 (ACTN4), but we failed to find causative mutations in these genes.
|
18594871 |
2008 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
In HCC cell lines, laminin alpha 5 heterotrimerized with beta and gamma chains and was secreted into the culture media.
|
18635166 |
2008 |
|
Colorectal Carcinoma
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
Colorectal Carcinoma
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
Colorectal Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
Malignant neoplasm of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
Adenocarcinoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
|
20972440 |
2010 |
|
Kidney Failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, mutation of a fifth (Lama5) gene in podocytes in mice causes proteinuria, nephrotic syndrome, and progression to renal failure.
|
21327778 |
2011 |
|
Colorectal Carcinoma
|
0.140 |
Biomarker
|
disease |
BEFREE |
Half of the Caucasian-identified variants, including the recently fine-mapped BMP pathway loci, BMP4, GREM1, BMP2 and LAMA 5, did not show any evidence for association with CRC in SCH (OR ~1; p-value >0.1).
|
22879968 |
2012 |