|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer.
|
16132575 |
2005 |
|
Adenocarcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Additionally, cores containing HGD and/or adenocarcinoma exhibited a higher number of peri-lesional stromal cells and a significant increase in peri-lesional stromal cell staining of LDHA and MCT4.
|
29170050 |
2018 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
To elucidate its role in tumor growth, we disrupted both the <i>LDHA</i> and <i>LDHB</i> genes in two cancer cell lines (human colon adenocarcinoma and murine melanoma cells).
|
30158244 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.
|
29756998 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
BEFREE |
In <i>in vivo</i> experiments, tumor growth was markedly inhibited by LDH-A silencing in a xenograft model of LUAD.
|
30509961 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of LDH5 isoenzyme (fully encoded by the LDHA gene) was assessed in human glioblastoma tissues.
|
28756228 |
2017 |
|
Adult Hepatocellular Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The miR-383-LDHA axis regulates cell proliferation, invasion and glycolysis in hepatocellular cancer.
|
28293396 |
2017 |
|
Adult Hepatocellular Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Lactate dehydrogenase A (LDHA), which is a key enzyme in the glycolysis signaling pathway, was found to be a target of miR‑34a in hepatocellular cancer cells.
|
26956717 |
2016 |
|
Adult Hepatocellular Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Inhibition of PDK4 and LDHA markedly suppresses CD133 (+) stemness characteristics and overcome resistance to sorafenib (current chemotherapeutic agent for hepatocellular cancer).
|
26506419 |
2015 |
|
Adult Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The effects of LDHA inhibition by oxamate or LDHA siRNA on medulloblastoma cell line metabolism, migration and proliferation were examined.
|
29601482 |
2018 |
|
Adult Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Gene-expression analysis of <i>MYC</i>-driven medulloblastoma cells revealed altered glucose metabolic pathways with marked overexpression of lactate dehydrogenase A (<i>LDHA</i>).
|
30862721 |
2019 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Maintenance of PDK1 or LDHA expression in certain regions of the brain may explain why some individuals tolerate high levels of Aβ deposition without developing Alzheimer disease.
|
22948140 |
2012 |
|
Anaplastic thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The highest relative phosphorylation levels of PKM2 and LDHA compared to overall expression were found in undifferentiated thyroid cancer.
|
25880801 |
2015 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, this study shows that enhanced glycolysis in PDGF- or FBS-stimulated VSMCs plays an important role in their proliferation and migration and suggests that LDHA is a potential therapeutic target to prevent vessel lumen constriction during the course of atherosclerosis and restenosis.
|
28818664 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, this study shows that enhanced glycolysis in PDGF- or FBS-stimulated VSMCs plays an important role in their proliferation and migration and suggests that LDHA is a potential therapeutic target to prevent vessel lumen constriction during the course of atherosclerosis and restenosis.
|
28818664 |
2017 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Upon investigating the molecular mechanism, LDHA knockdown via siRNA treatment was associated with decreased cyclin D1 expression, increased cleavage of PARP, and altered B-cell lymphoma 2 and B-cell lymphoma 2-associated protein X expression.
|
29552147 |
2018 |
|
Benign Prostatic Hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In current study, we observed overexpression of LDHA in the clinical prostate cancer samples compared with benign prostate hyperplasia tissues as demonstrated by immunohistochemistry and real-time qPCR.
|
25983002 |
2015 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
In the present study, we investigated the mRNA expression levels of HIF-1 (α and β) and its target genes (VEGF, GLUT1, PGK1, PFKFB3, and LDHA) in the peripheral white blood cells of patients with major depressive disorder (MDD) and bipolar disorder (BPD).
|
23333658 |
2013 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.
|
28978061 |
2017 |
|
Bladder Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hypoxia-induced circular RNA has_circRNA_403658 promotes bladder cancer cell growth through activation of LDHA.
|
31814891 |
2019 |
|
Borderline Personality Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the mRNA expression levels of HIF-1 (α and β) and its target genes (VEGF, GLUT1, PGK1, PFKFB3, and LDHA) in the peripheral white blood cells of patients with major depressive disorder (MDD) and bipolar disorder (BPD).
|
23333658 |
2013 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The current knowledge of the role of LDHA in the brain and its potential as a therapeutic target for brain tumors will also be highlighted.
|
26269128 |
2016 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
|
30688660 |
2019 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In total, targeting LDHA opened a novel strategy to interrupt autophagy and tamoxifen resistance in breast cancer.
|
30878502 |
2019 |