|
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression.
|
24634381 |
2014 |
|
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings highlight p53 status in pancreatic cancer as a biomarker to predict sensitivity to LDH-A inhibition, with regard to both real-time noninvasive imaging by 13C MRS as well as therapeutic response.
|
26113084 |
2015 |
|
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We found a negative correlation between KLF4 and LDHA expression in pancreatic cancer cells and tissues and that their expression was associated with clinicopathologic features of pancreatic cancer.
|
24947925 |
2014 |
|
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
BEFREE |
Taken together, our study revealed the oncogenic role of LDHA in pancreatic cancer and suggested that LDHA might be a potential therapeutic target.
|
23404405 |
2013 |
|
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that c-Myc and LDHA are concomitantly overexpressed in pancreatic cancer cell lines and clinical specimens. c-Myc overexpression and LDHA overexpression were correlated with TNM stage and tumor size and indicated poor prognosis in patients with pancreatic cancer.
|
26021472 |
2015 |
|
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers.
|
23523103 |
2013 |
|
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
BEFREE |
The targeting of glycolytic enzymes such as PKM2 and LDHA represents a promising therapeutic approach for the treatment of pancreatic cancer.
|
31527446 |
2019 |
|
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, HK1, PKLR, and LDHA expression correlated positively with PC progression.
|
31689601 |
2020 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.
|
29756998 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
BEFREE |
In <i>in vivo</i> experiments, tumor growth was markedly inhibited by LDH-A silencing in a xenograft model of LUAD.
|
30509961 |
2019 |
|
Mental Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Further results proved that AS modulated energy metabolism in depression through the inhibition of the expression of pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK-1) and lactate dehydrogenase A (LDHA).
|
30894817 |
2019 |
|
Pancreatic Neoplasm
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Expression of KLF4 and lactate dehydrogenase A (LDHA) in 70 primary pancreatic tumors and 10 normal pancreatic tissue specimens was measured.
|
24947925 |
2014 |
|
Major Depressive Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We also found increased expression of HIF-1α and LDHA mRNA in MDD patients in a remissive state, whereas the mRNA expression levels of other genes in a remissive state were comparable to those in healthy control subjects.
|
23333658 |
2013 |
|
Hyperglycemia
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
The accumulation of HIF-1α induced by hyperglycemia increases LDHA activity and HK2, PFKP expression, thereby promoting pancreatic glycolysis to facilitate cancer progression.
|
31241439 |
2019 |
|
Muscular stiffness
|
0.110 |
Biomarker
|
phenotype |
BEFREE |
Otherwise, patients with a lactate dehydrogenase M-subunit deficiency do not show muscle stiffness and myoglobinuria under ordinary circumstances.
|
3383424 |
1988 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting LDHA through miR-34a could be a potential therapeutic strategy in breast cancer.
|
26902416 |
2016 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims to explore the potential medicinal application of SS for LDH-A inhibition on breast cancer and to determine its bioactive compounds.
|
23457597 |
2013 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
|
30688660 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings provide clues regarding the role of miR-30a-5p as a tumor suppressor in breast cancer through the inhibition of LDHA.
|
28461244 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that MTA1 expression is positively correlated with the LDHA expression levels in breast cancer patients.
|
31570164 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we showed that BA could inhibit aerobic glycolysis activity in breast cancer cell lines MCF-7 and MDA-MB-231 by hampering lactate production, glucose uptake and extracellular acidification rate (ECAR), as well as suppressing aerobic glycolysis-related proteins including c-Myc, lactate dehydrogenase A (LDH-A) and p-PDK1/PDK1 (pyruvate dehydrogenase kinase 1).
|
30684465 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simultaneously targeting PDL1 and LDHA, which would combine immunotherapy and metabolically targeted treatments, might shed some light on the treatment of breast cancer, especially TNBC.
|
28915924 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, LDHA and AMPK were detected by immunohistochemistry (IHC) using breast cancer tissue microarrays (TMAs) of 112 patients.
|
27598996 |
2016 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our findings showed that repression of LDHA induced by wt-p53 blocks tumor growth and invasion through downregulation of aerobic glycolysis in breast cancer, providing new insights into the mechanism by which p53 contributes to the development and progression of breast cancer.
|
30618169 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study shows that signal transducer and activator of transcription 3 (STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma.
|
31086462 |
2019 |