|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The evidence of linkage for leptin levels is consistent with prior linkage analyses for cholesterol, hypertension and other metabolic phenotypes.
|
15611783 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Growing evidence suggests that concentration of the adipocytokines leptin and adiponectin may be affected by risk of hypertension during pregnancy.
|
16785148 |
2006 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Familial obesity, sympathetic activation and blood pressure level.
|
11800057 |
2001 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Subjects with stage I hypertension had significantly higher plasma leptin levels than normotensive subjects.
|
9832173 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
The major finding from the present study was that the natural rise in plasma leptin with weight-gain is insufficient to counterbalance high blood pressure associated with obesity, additional increases of circulating leptin levels with adenoviral leptin gene therapy led to normalisation of blood pressure in high-fat diet-induced obese and hypertensive rats.
|
20059648 |
2010 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Interaction between leptin and sympathetic nervous system in hypertension.
|
10981165 |
2000 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To examine if leptin induces hypertension acting on the CB Trpm7.
|
31545149 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this meta-analysis, we summarized the association of the II/I polymorphism in leptin gene and Gln223Arg polymorphism in LEPR gene with hypertension and circulating leptin.
|
25475696 |
2015 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Several signalling pathways have been studied and related to the development and progression of RH: modulation of sympathetic activity by leptin and aldosterone, primary aldosteronism, arterial stiffness, endothelial dysfunction and variations in the renin-angiotensin-aldosterone system (RAAS). miRNAs comprise a family of small non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. miRNAs are involved in the development of both cardiovascular damage and hypertension.
|
29184046 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results showing that higher blood pressure levels were found with the most prevalent -2548G>A genotype, whereas patients with the AA genotype seemed to be protected from hypertension, indicate that the -2548G>A polymorphism of LEP appears to be an important mediator of obesity hypertension.
|
19229195 |
2009 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats.
|
25205467 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In this study, we identified the variables that predict BP response to CPAP.24-h ambulatory BP monitoring (ABPM), C-reactive protein (CRP), leptin, adiponectin and 24-h urinary catecholamine were measured before and after 6 months of CPAP in obstructive sleep apnoea (OSA) patients.Overall, 88 middle-aged, obese male patients with severe OSA (median apnoea-hypopnoea index 42 events·h<sup>-1</sup>) were included; 28.4% had hypertension.
|
28982776 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension.
|
27226618 |
2016 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Chronic hyperinsulinemia due to insulin resistance, high plasma levels of leptin, and/or obstructive sleep apnea may be responsible for sympathetic overactivity in obesity-related hypertension.
|
31087350 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The leptin gene polymorphism was associated with hypertension independent of obesity.
|
12050272 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The clinical potential of this pathway remains under investigation; however, existing data indicate that a sex discrepancy exists in mechanisms of leptin-mediated hypertension between males and females and that leptin-stimulated aldosterone plays a significant role in females.
|
30678859 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These novel findings provide important evidence that HDL and leptin maybe possibly mediate the process of CYP17A1 involved in hypertension.
|
29338791 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In obese subjects, several mechanisms may lead to hypertension such as insulin and leptin resistance, perivascular adipose tissue dysfunction, renal impairment, renin-angiotensin-aldosterone-system activation and sympathetic nervous system activity.
|
31330870 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Serum leptin levels correlation with high blood pressure in adult females.
|
16827954 |
2006 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that the Gln223Arg polymorphism of the leptin receptor is significantly associated with plasma leptin levels and left ventricular hypertrophy in hypertension.
|
24485307 |
2013 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
[Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy].
|
18050615 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
The leptin gene polymorphism was associated with hypertension independent of obesity.
|
12050272 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Relationship between changes in serum leptin levels and blood pressure after weight loss.
|
12484512 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Specific mutations in the leptin and the melaninocortin receptor genes in animal models of obesity without hypertension, the actions of α-melanocyte stimulating hormone, and SNS activity in obesity-related hypertension may promote recognition of protective and promoting factors for hypertension in obesity.
|
26103132 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It was also shown that the adipocyte-derived hormone leptin is a new direct regulator of aldosterone secretion and that leptin-mediated aldosterone production is a major contributor to obesity-associated hypertension in women.
|
29957022 |
2018 |