|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Subjects with stage I hypertension had significantly higher plasma leptin levels than normotensive subjects.
|
9832173 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
While plasma angiotensinogen and blood pressure were positively correlated only in subjects with a positive family history of hypertension (r=0.33, P< 0.05), plasma leptin was related to blood pressure in both groups (r=0.26, P=0.01).
|
9814618 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results suggest a role for leptin in obesity-related hypertension, especially in adolescents.
|
9886890 |
1998 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans.
|
9622134 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Interaction between leptin and sympathetic nervous system in hypertension.
|
10981165 |
2000 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
When BMI and leptin are elevated, increased blood pressure is found only with the most prevalent LEPR genotype at codons 109 and 223, whereas variants of this receptor seem to protect from hypertension.
|
10999797 |
2000 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Familial obesity, sympathetic activation and blood pressure level.
|
11800057 |
2001 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The leptin gene polymorphism was associated with hypertension independent of obesity.
|
12050272 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
The leptin gene polymorphism was associated with hypertension independent of obesity.
|
12050272 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Relationship between changes in serum leptin levels and blood pressure after weight loss.
|
12484512 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Collectively, our data suggest the pathophysiologic and therapeutic implication of leptin in obesity-related insulin resistance and hypertension.
|
11872379 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-beta1.
|
12219869 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We found no association among hypertension, BMI, and leptin levels with beta3-adrenergic receptor genotypes.
|
14739355 |
2004 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The evidence of linkage for leptin levels is consistent with prior linkage analyses for cholesterol, hypertension and other metabolic phenotypes.
|
15611783 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Growing evidence suggests that concentration of the adipocytokines leptin and adiponectin may be affected by risk of hypertension during pregnancy.
|
16785148 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Serum leptin levels correlation with high blood pressure in adult females.
|
16827954 |
2006 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients.
|
17114907 |
2006 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
[Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy].
|
18050615 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In established hypertension, elevated CRP was associated with increased BP, BMI, insulin, HOMA (index of insulin resistance), leptin, triglycerides and norepinephrine.
|
17211240 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Hyperleptinemia is associated with hypertension in Japanese males.
|
18596833 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
To examine the association of a common -2548G/A (rs7799039) promoter variant of the human leptin gene (LEP) with obesity or body mass index (BMI) and its associated phenotypes such as blood pressure variability and the prevalence of hypertension in a sample of the Tunisian population.
|
18923972 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results showing that higher blood pressure levels were found with the most prevalent -2548G>A genotype, whereas patients with the AA genotype seemed to be protected from hypertension, indicate that the -2548G>A polymorphism of LEP appears to be an important mediator of obesity hypertension.
|
19229195 |
2009 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that LEP gene variants could be related to depression and associated co-morbidities such as hypertension.
|
19382181 |
2009 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
We identified significant associations between LEPTIN single nucleotide polymorphisms with blood pressure and hypertension, but in postmenopausal women only.
|
19204185 |
2009 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
There are several known factors implicating this association, e.g. high blood pressure leads to remodeling of the carotid arterial wall, to its stiffness and to a diminished activation of baroreceptors; leptin released from a fatty tissue activates the sympathetic nervous system etc.
|
19093712 |
2009 |