|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-beta1.
|
12219869 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Leptin in association with common variants of MC3R mediates hypertension.
|
24487982 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Leptin is a hormone made by adipocytes and associated with hypertension, inflammation, and coronary artery disease.
|
27666945 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Leptin appears as a new direct regulator of adrenal aldosterone production and leptin-mediated aldosterone production is a novel candidate mechanism underlying obesity-associated hypertension, particularly in females.
|
29135585 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight).
|
31691260 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats.
|
25205467 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Adipokines, including adiponectin and leptin, and renin-angiotensin-aldosterone system (RAAS) contribute to hypertension.
|
31236708 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Animal studies have shown that leptin mediates the association between obesity and hypertension.
|
30896657 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension.
|
27226618 |
2016 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Chronic hyperinsulinemia due to insulin resistance, high plasma levels of leptin, and/or obstructive sleep apnea may be responsible for sympathetic overactivity in obesity-related hypertension.
|
31087350 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Class I/I genotypes of leptin showed significantly high risk for developing hypertension irrespective of obesity.
|
24171506 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Collectively, our data suggest the pathophysiologic and therapeutic implication of leptin in obesity-related insulin resistance and hypertension.
|
11872379 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Compared to controls, patients presented significantly lower levels of cholesterol, high-density lipoprotein cholesterol (HDLc), LDLc, oxLDL, and intermediate and small HDL and higher triglycerides, CRP, adiponectin, large HDL, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein- (IDL) B. Adiponectin levels correlated positively with large HDL and negatively with intermediate and small HDL, oxLDL/LDLc, and BMI; patients with DM (<i>n</i> = 17) and with DM+HT (<i>n</i> = 70), as compared to patients without DM or HT (<i>n</i> = 69) or only with HT (<i>n</i> = 38), presented significantly higher oxLDL, oxLDL/LDLc, and leptin and lower adiponectin.
|
30911344 |
2019 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Contrary to our expectations, even before leptin substitution, 1 patient with biallelic leptin receptor gene variants and 4 patients with leptin deficiency had been suffering from hypertension.
|
31357197 |
2019 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Familial obesity, sympathetic activation and blood pressure level.
|
11800057 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Finally, it might be postulated that alterations of mitochondrial dynamics in white adipose tissue could contribute to the development and maintenance of hypertension in obesity situations through leptin overproduction.
|
28233236 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the Gln223Arg polymorphism was significantly associated with plasma leptin levels (p<0.001), while no correlations between Lys109Arg SNP and hypertension were found.
|
22293279 |
2012 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans.
|
9622134 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Given that adipocytokines may play an important role in the pathophysiology of high blood pressure (HBP) and because related reports in children are scarce and controversial, we evaluated the relationship of leptin, resistin, tumor necrosis factor-α, interleukin-6, adiponectin, and interferon-γ with HBP.<b>Materials and Methods</b>.
|
31042407 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Growing evidence suggests that concentration of the adipocytokines leptin and adiponectin may be affected by risk of hypertension during pregnancy.
|
16785148 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hence, central leptin employs TNFα to mediate the diurnal blood pressure elevation in physiology while enhancement of this mechanism can contribute to hypertension development.
|
27226618 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hence, neural control of blood pressure is mediated by a signaling network between leptin, TNFα, melanocortin, and glutamate and changes in dynamics due to central excess leptin and TNFα mediate the switch from normal physiology to obesity-related hypertension.
|
28419227 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Hyperleptinemia is associated with hypertension in Japanese males.
|
18596833 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In addition to NPY-mediated energy homeostasis, leptin-melanocortin activation may be essential for metabolic disturbance-related hypertension.
|
31659606 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In comparison of controlled and uncontrolled hypertensive patients, leptin was significantly higher in uncontrolled hypertensive patients (p < 0.001).<b>Conclusion</b>: Comparing two groups of hypertensive and normotensive subjects, leptin is found to be positively correlated with hypertension in both genders.
|
30582364 |
2020 |