Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been systematically examined.
|
17229951 |
2007 |
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development.
|
26441241 |
2015 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
These include the hormone leptin, the short and long forms of the leptin receptor, uncoupling proteins, agouti protein, melanocortin receptor isoforms, melanin-concentrating hormone, and the proteins responsible for tub and fat, two monogenic mouse models of obesity.
|
9625380 |
1998 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, it is unlikely that mutations in the coding region of the long isoform of the leptin receptor are a common cause of juvenile onset obesity.
|
9144432 |
1997 |
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression.
|
25132556 |
2014 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This demonstrates an association between variation at the leptin receptor gene and obesity in humans.
|
9158141 |
1997 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways.
|
30611982 |
2019 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since CCX140-B has a low affinity for mouse CCR2, transgenic human CCR2 knockin mice were generated and rendered diabetic with either a high-fat diet (diet-induced obesity) or by deletion of the leptin receptor gene (db/db).
|
23986513 |
2013 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Congenital deficiency of the leptin receptor is a very rare cause of severe early-onset obesity.
|
21306929 |
2011 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Leptin plays an important role in the regulation of body fat homeostasis, and potential associations of leptin receptor gene (LEPR) polymorphisms with obesity have been suggested.
|
16011872 |
2006 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Lys656Asn polymorphism of LEPR gene is associated with obesity parameters, insulin resistance and glucose levels in patients with NAFLD.
|
22530350 |
2012 |
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis.
|
22609345 |
2012 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
LEPR rs1137101 GG genotype was related to reduced risk of obesity (odds ratio [OR] 0.26, 95% confidence interval [CI] 0.08-0.79; p = 0.018) and MetS (OR 0.36, 95% CI 0.15-0.88; p = 0.024), but it was not significant after Bonferroni correction for multiple tests as compared to the AA genotype (p > 0.01).
|
28975585 |
2018 |
Obesity
|
0.700 |
Biomarker
|
disease |
RGD |
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals.
|
22693203 |
2012 |
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents.
|
12150780 |
2002 |
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
The long form of leptin receptor (Ob-R(b)) is required for satiety; mice lacking this receptor (db/db mice) are also substantially obese.
|
16373670 |
2006 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity.
|
23616257 |
2014 |
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.
|
12651605 |
2003 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Variations in the Obesity Gene "LEPR" Contribute to Risk of Type 2 Diabetes Mellitus: Evidence from a Meta-Analysis.
|
27195302 |
2016 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity did not correlate with protein serum levels.We observed that obesity is more frequent in children with LEPR 223 AG+GG and LEPR 1019 GA+AA genotypes.
|
27015185 |
2016 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Four-week-old male leptin receptor-knockout db/db mice were used as controls for a model of obesity retaining low testosterone.
|
29895265 |
2018 |
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although the effects of leptin have been more thoroughly documented in nonprimate species than in primates, a few human families with genetic mutations of the gene for leptin or the leptin receptor show obesity and impaired fertility.
|
12087500 |
2002 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The typing of two microsatellite markers (D1S198 and D1S209), flanking the OBR gene, in 256 sib pairs showed no evidence for linkage with obesity.
|
9341859 |
1997 |
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP.
|
11532192 |
2001 |
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently published results revealed linkage of obesity traits to a chromosomal region near the leptin receptor gene (Lepr) locus in high body weight selected big and fat DU6i mice.
|
12951635 |
2003 |