|
Obesity
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
"Endocrine pancreatic cells of postnatal ""diabetes"" (db) mice in cell culture."
|
393618 |
1979 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
"Estrone treatment dissociates primary versus secondary consequences of ""diabetes"" (db) gene expression in mice."
|
3519326 |
1986 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Initially to investigate the effect of obesity and IR in the analyzed parameters, insulin-sensitive eutrophic volunteers (CON; <i>n</i> = 9) and obese non-insulin (OB; <i>n</i> = 9) and insulin-resistant (OBR; <i>n</i> = 8) were enrolled.
|
30429793 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> We showed that serum miR-27a level correlated positively with obesity and insulin resistance in obese children, and that elevated serum miR-27a levels correlated with insulin resistance in leptin receptor-deficient db/db mice, and with obesity and insulin resistance in high-fat diet-fed C57BL/6J mice.
|
29721071 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and 805 controls.
|
15159310 |
2004 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related leptin receptor polymorphisms are not associated with gallstones disease.
|
16807515 |
2006 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity did not correlate with protein serum levels.We observed that obesity is more frequent in children with LEPR 223 AG+GG and LEPR 1019 GA+AA genotypes.
|
27015185 |
2016 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
LEPR-109 polymorphism in premenopausal women appears to be associated with obesity and tumor progression.
|
18004080 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Leptin receptor gene mutations are a very rare cause of severe early-onset obesity.
|
22308862 |
2011 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
LEPR haplotype 3 (AGG: 109Lys/233Arg/656Lys) carriers have increased risk for obesity (OR: 2.56, 95% CI: 1.19-5.49, p = 0.017).
|
24402012 |
2013 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
LEPR rs1137101 GG genotype was related to reduced risk of obesity (odds ratio [OR] 0.26, 95% confidence interval [CI] 0.08-0.79; p = 0.018) and MetS (OR 0.36, 95% CI 0.15-0.88; p = 0.024), but it was not significant after Bonferroni correction for multiple tests as compared to the AA genotype (p > 0.01).
|
28975585 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
LEPR has diverse roles in metabolism, appetite and bone formation with obesity linked to both elevated levels of leptin and increased cancer incidence.
|
29212170 |
2017 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity.
|
9545018 |
1998 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Lys656Asn polymorphism of LEPR gene is associated with obesity parameters, insulin resistance and glucose levels in patients with NAFLD.
|
22530350 |
2012 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
|
9537324 |
1998 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization.
|
6993269 |
1980 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
A reproductive endocrine profile in the diabetes (db) mutant mouse.
|
378276 |
1979 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been systematically examined.
|
17229951 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been systematically examined.
|
17229951 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice.
|
31076350 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.
|
29551634 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice.
|
12540618 |
2003 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Also mutations in the Ob receptor gene result in marked obesity in rodents.
|
10395194 |
1999 |