|
Obesity
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Diabetes, a new mutation in the mouse.
|
5918576 |
1966 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria.
|
5009970 |
1972 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Studies of diabetic nephropathy in animals and man.
|
823065 |
1976 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Primary myocardial disease in the diabetic mouse. An ultrastructural study.
|
431046 |
1979 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
A reproductive endocrine profile in the diabetes (db) mutant mouse.
|
378276 |
1979 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
"Endocrine pancreatic cells of postnatal ""diabetes"" (db) mice in cell culture."
|
393618 |
1979 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Diabetic neuropathy in the mutant mouse [C57BL/ks(db/db)]: a morphometric study.
|
6991317 |
1980 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization.
|
6993269 |
1980 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Anti-pancreatic immunity in genetically diabetic mice.
|
6339122 |
1983 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Description of a new model of genetic obesity: the dbPas mouse.
|
3882910 |
1985 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
"Estrone treatment dissociates primary versus secondary consequences of ""diabetes"" (db) gene expression in mice."
|
3519326 |
1986 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
|
8177042 |
1994 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therapeutic approaches to the treatment of obesity based on OB protein ranging from OB protein by injection to OB-R receptor agonists and to upregulation of OB signalling pathways are under intense investigation.
|
9013731 |
1996 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
RGD |
Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat.
|
8841178 |
1996 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, defects in the ob gene and leptin receptor gene have been demonstrated to be the cause of obesity in several rodent models.
|
8982734 |
1996 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
RGD |
These facts suggest that the substitution at codon 269 of the OB-R cDNA represents the crucial mutation which results in the obese phenotype of Zucker (fa/fa) rat.
|
8702432 |
1996 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
There was no difference in the amount of leptin-receptor mRNA In seven lean (BMI 23.3 +/- 0.9 kg/m2) and eight obese (BMI 36.9 +/- 1.5) subjects as determined by reverse transcription-polymerase chain reaction.
|
8666155 |
1996 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, it is unlikely that mutations in the coding region of the long isoform of the leptin receptor are a common cause of juvenile onset obesity.
|
9144432 |
1997 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This demonstrates an association between variation at the leptin receptor gene and obesity in humans.
|
9158141 |
1997 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The typing of two microsatellite markers (D1S198 and D1S209), flanking the OBR gene, in 256 sib pairs showed no evidence for linkage with obesity.
|
9341859 |
1997 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using both parametric and nonparametric methods, we found no evidence of linkage of obesity to any of nine candidate genes/regions, including the Prader-Willi chromosomal region (PWS), the human homologue of the mouse agouti gene (ASP), and the genes for leptin (OB), the leptin receptor (OBR/DB), the beta3-adrenergic receptor (ADRB3), lipoprotein lipase (LPL), hepatic lipase (LIPC), glycogen synthase (GYS), and tumor necrosis factor alpha (TNFA).
|
9326333 |
1997 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice.
|
9299565 |
1997 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To explore whether mutations in the Ob-R gene cause obesity in humans, we have searched for mutations in the gene for Ob-Rb, a biologically active receptor isoform, in obese Japanese subjects.
|
9349603 |
1997 |