|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease.
|
25849351 |
2015 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
The FADS1 rs174547 CC variant was also associated with significantly increased CHD risk compared with the TT and TC variant (adjusted OR=1.53, 95%CI: 1.01-2.31), and the effect was more evident among nonsmokers and females.
|
22490578 |
2012 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Fatty acid profile in plasma cholesteryl esters and FADS1 genotype at baseline were measured in a random subcohort (n = 1323) and incident CHD cases (n = 537).
|
22911844 |
2012 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
Delta-5 and delta-6 desaturases, FADS1 and FADS2, respectively, influence the serum, plasma and membrane phospholipid levels of LA, ALA and long-chain polyunsaturated fatty acids during pregnancy, lactation, and may influence an infant's IQ, atopy and coronary heart disease (CHD) risk.
|
20558833 |
2010 |
|
Malignant Neoplasms
|
0.140 |
Biomarker
|
group |
BEFREE |
Since histone deacetylase inhibitors have been well-known to suppress cancer cell migration and invasion, we thus tested whether knockdown of delta-5-desaturase and DGLA treatment could also be used to inhibit cancer migration and invasion of colon cancer and pancreatic cancer cells.
|
28157665 |
2017 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Malignant Neoplasms
|
0.140 |
AlteredExpression
|
group |
BEFREE |
We thus hypothesize that the commonly overexpressed COX in cancer (~90% of colon cancer patients) can be taken advantage to suppress cell growth by knocking down delta-5-desaturase (D5D, a key enzyme that converts DGLA to arachidonic acid).
|
27101738 |
2016 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
BEFREE |
Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.
|
22140540 |
2011 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
BEFREE |
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
|
20691134 |
2010 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Genes subject to cis-eQTL effects that were common to both CD4+ and B lymphocytes at RA risk loci were FADS1, FADS2, BLK, FCRL3, ORMDL3, PPIL3, and GSDMB.
|
29193869 |
2018 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population.
|
30531795 |
2018 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.
|
28115744 |
2018 |
|
Laryngeal Squamous Cell Carcinoma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
The fatty acid desaturase 1 (FADS1) gene variant is a novel susceptibility marker for laryngeal squamous cell carcinoma identified by a recent genome-wide association study, but it is still unclear whether this genetic variant continues to influence oral cancer recurrence or death.
|
27542551 |
2017 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Laryngeal Squamous Cell Carcinoma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.
|
25194280 |
2014 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we evaluated the influence of the FADS1 FADS2 gene cluster polymorphisms on the association between BF and asthma.
|
21933193 |
2012 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
|
30698716 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |