|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD).
|
30234895 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population.
|
31186284 |
2019 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
However, clinical impacts of lipoprotein(a) levels on adverse vascular events in patients with established coronary artery disease who are undergoing statin treatment have not been fully elucidated.
|
31577620 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a).
|
24530664 |
2014 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated levels of lipoprotein(a) [Lp(a)] and the presence of small isoforms of apolipoprotein(a) [apo(a)] have been associated with coronary artery disease (CAD) in whites but not in African Americans.
|
11116062 |
2000 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein (a) (Lp(a)), a well-established risk factor for coronary artery diseases (CAD), would also be anticipated to be associated in a similar manner with risk of type 2 diabetes mellitus (T2DM) based on the common soil hypothesis of etiology of T2DM and CAD.
|
28132096 |
2017 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease.
|
29103916 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We examined the effects of family history of coronary artery disease (CAD), apolipoprotein E (apo E) phenotype, and lipoprotein(a) [Lp(a)] on the response of plasma lipids to change in dietary lipid intake after 3 mo of nutrition education in 125 children aged 4-10 y.
|
9356540 |
1997 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) and Cardiovascular Outcomes in Patients With Coronary Artery Disease and Prediabetes or Diabetes.
|
31076417 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Serum lipoprotein (a) concentrations (Lp(a)) are largely under genetic control, and are strong predictors of coronary heart disease.
|
8800499 |
1996 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We for the first time explored the association of the four SNPs in the SLC22A3-LPAL2-LPA gene cluster with CAD in a large Chinese Han sample.
|
23036009 |
2012 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The variant allele of rs3798220 in the apolipoprotein(a) gene (LPA) is used to assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with short alleles of the Kringle IV-2 (KIV-2) copy number variation (CNV) and high lipoprotein(a) (Lp(a)) concentrations.
|
26302166 |
2015 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
High plasma lipoprotein(a) [Lp(a)] levels have been implicated as an independent risk factor for coronary artery disease in Caucasians, Chinese, Africans, and Indians.
|
11001801 |
2000 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p<10(-33); LPA:p<10(-19); 1p13.3:p<10(-17)) as well as three recently discovered loci (COL4A1/COL4A2, ZC3HC1, CYP17A1:p<5×10(-7)).
|
21966275 |
2011 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
We found 1 SNP that was associated with severe CAD: LPA I4399M (rs3798220).
|
17569884 |
2007 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD.About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile).
|
31481563 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the rs3798220, rs10455872 and rs6415084 single-nucleotide polymorphisms (SNPs) in the Lp(a) gene (LPA) correlate with elevated Lp(a) levels, but whether these SNPs have prognostic value for CAD patients is unknown.
|
23978127 |
2013 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The median follow-up was 9·9 years.Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1·44, 95% CI 1·14-1·83) and the presence of either LPA SNP (1·88, 1·40-2·53).
|
28566218 |
2017 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
After adjusting for age, sex, and current smoking status, there were no significant differences between patients with or without CAD in lipoprotein(a), homocysteine, fibrinogen, plasminogen activator inhibitor-1, white blood cell count, body mass index, glucose, triglyceride or total cholesterol.
|
15547022 |
2004 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relatively low numbers of kringle 4 type 2 repeats in apolipoprotein(a) and specific haplotypes of the SLC22A3-LPAL2-LPA region on chromosome 6 are associated with an increased risk of coronary disease.
|
23278389 |
2013 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Relevance of post-methionine homocysteine and lipoprotein (a) in evaluating the cardiovascular risk in young CAD patients.
|
15638812 |
2005 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein (a) and Low-density lipoprotein apolipoprotein B metabolism following apheresis in patients with elevated lipoprotein(a) and coronary artery disease.
|
30447089 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Finally, we compared phenotypic versus genotypic ORs to estimate whether apolipoprotein(a) isoform size, lipoprotein(a) concentration, or both were causally associated with coronary heart disease.
|
28408323 |
2017 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Circulating transforming growth factor-beta1, lipoprotein(a) and cellular adhesion molecules in angiographically assessed coronary artery disease.
|
12940514 |
2003 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although a family history of coronary artery disease (CAD) is an established factor influencing lipoprotein(a) [Lp(a)] levels, the effect of sex on Lp(a) concentration remains unclear.
|
21519277 |
2011 |