|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges.
|
2976021 |
1988 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] is a macromolecular complex found in human plasma that combines structural elements from the lipoprotein and blood clotting systems and that is associated with premature coronary heart disease and stroke.
|
2530631 |
1989 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Prevalence of lipoprotein (a) [Lp(a)] excess in coronary artery disease.
|
1827234 |
1991 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The value of lipoprotein (a) [Lp(a)] in the prediction of coronary artery disease risk very early in life remains to be established in different racial groups.
|
1829398 |
1991 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein (a) (Lp(a)) is a low density lipoprotein-like particle which contains the plasminogen-like apolipoprotein a. Lp(a) levels are elevated in patients with atherosclerotic coronary artery disease.
|
1824942 |
1991 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Intermediate-density lipoproteins (IDLs) and lipoprotein (a) are highly atherogenic species that each normally account for up to 10% to 15% total LDL cholesterol but may be disproportionately elevated in pathologic states and may therefore contribute disproportionately to coronary disease risk in certain patients.
|
1994714 |
1991 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a). A genetic risk factor for premature coronary heart disease.
|
1534588 |
1992 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart disease.
|
1541665 |
1992 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) and coronary heart disease.
|
8187239 |
1994 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Whereas the importance of plasma lipoprotein(a) [Lp(a)] levels as a risk factor for premature coronary artery disease (CAD) is certain, it is not clear if the apolipoprotein(a) [apo(a)] phenotype plays an additional and independent role.
|
8059696 |
1994 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein(a) levels were strongly associated with coronary artery disease in five of seven prospective studies but were not associated in two of the four largest studies.
|
8185133 |
1994 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The relation of LDL receptor activity to lipoprotein(a) plasma concentration in patients without coronary artery disease.
|
8187228 |
1994 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic effect of apolipoprotein(a) and apolipoprotein E polymorphisms on plasma quantitative risk factors for coronary heart disease in American black women.
|
8546757 |
1995 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the I/D polymorphism of the ACE gene is an important independent risk factor for coronary artery disease and is more predictive that lipoprotein(a).
|
7882471 |
1995 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that the apo(a) gene is the major determinant of Lp(a) serum levels not only in the general population but also in a high-risk CAD population.
|
7825589 |
1995 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Serum lipoprotein (a) concentrations (Lp(a)) are largely under genetic control, and are strong predictors of coronary heart disease.
|
8800499 |
1996 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
No apparent association between the VNTR genotype and plasma lipid concentration was observed; however, for the same genotype, the CAD and stroke patients frequently showed higher lipoprotein(a) and lower HDL cholesterol concentrations than the control group.
|
8665685 |
1996 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a)-apheresis in the secondary prevention of coronary heart disease.
|
10168548 |
1996 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein(a) kringle IV repeat number predicts risk for coronary heart disease.
|
8640397 |
1996 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Correlation of toddlers' serum lipoprotein(a) concentration with parental values and grandparents' coronary heart disease: the STRIP baby study.
|
8740296 |
1996 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein(a) and pentanucleotide repeat polymorphisms are associated with the degree of atherosclerosis in coronary heart disease.
|
8782849 |
1996 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease.
|
9125314 |
1996 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Some reports have suggested that plasma lipoprotein(a) [Lp(a)] levels may explain such variation and that FH subjects deficient in LDL receptors, especially those with coronary heart disease, tend to have elevated Lp(a) levels.
|
8548413 |
1996 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We examined the effects of family history of coronary artery disease (CAD), apolipoprotein E (apo E) phenotype, and lipoprotein(a) [Lp(a)] on the response of plasma lipids to change in dietary lipid intake after 3 mo of nutrition education in 125 children aged 4-10 y.
|
9356540 |
1997 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
A unique construct of low-density lipoprotein (LDL), lipoprotein[a] has been shown to be a valuable independent risk factor for coronary artery disease.
|
9170891 |
1997 |