Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, we replicated the LPL and CETP loci previously found to be associated with MetS in Europeans.
|
26507551 |
2015 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
22399527 |
2012 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes.
|
27827461 |
2016 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel African American-specific variant, rs12721054/APOC1, and rs10096633/LPL are associated with ≥3 MetS components.
|
25023634 |
2014 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS.
|
30381540 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.
|
17555736 |
2007 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis after adjustment for age, sex, adiponectin and S447X polymorphism demonstrated that LPL mass was inversely associated with CHD in men and both genders (p=0.02), with hypertension confined to women (p=0.04) and with MS likelihood in both genders combined and women [odds ratio 1.51 (95% CI 1.14-2.00) for halving the likelihood].
|
19191728 |
2009 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study shows that carrier status of one defective lipoprotein-lipase allele is associated with impaired insulin sensitivity, an atherogenic lipoprotein profile and other characteristics of the metabolic syndrome, which are risk factors for atherosclerotic vascular disease.
|
11914743 |
2002 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This haplotype-based genetic analysis provides compelling evidence that variation in the LPL gene plays a role in determining insulin resistance in this ethnic group with a high prevalence of the insulin resistance syndrome.
|
14693718 |
2004 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the relationship between two common LPL variants and the presence of MetS and its individual components.
|
27676127 |
2016 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013).
|
24200052 |
2014 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
22399527 |
2012 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study has shown that the S1 allele of APOC3 SstI polymorphism and the H- allele of LPL HindIII polymorphism might have a small effect on apoB levels in the Central European Caucasian population with dyslipidemia of metabolic syndrome.
|
16343038 |
2006 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gender-related relation between metabolic syndrome and S447X and HindIII polymorphisms of lipoprotein lipase gene in northern Iran.
|
31034941 |
2019 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population.
|
30382898 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We assessed lipid levels and the frequencies of the cholesteryl ester transfer protein (CETP) Taq-1 B, lipoprotein lipase (LPL)S447X, -93 T/G, apolipoprotein B (APO B) 96bp ins/del, lipoprotein(a) (LP[a]) pentanucleotide repeat, and apolipoprotein E (APO) E epsilon 2/3/4 polymorphisms in relation to the metabolic syndrome using both National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) definitions.
|
19642912 |
2009 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The LPL polymorphism contributed to the severity of coronary disease in patients with MS and recent ACS.
|
29412239 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutations in the lipoprotein lipase gene causing decreased lipoprotein lipase activity are associated with surrogate markers of insulin resistance and the metabolic syndrome in humans.
|
28502509 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This presumed impaired effect of insulin on LPL postprandially could be an important contributor to the atherogenic dyslipidaemia described in insulin resistance syndrome.
|
11895454 |
2002 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This was the first study this kind to show an association between LPL and large VLDL particle size within the MetS, a pattern associated with higher IR.
|
21854610 |
2011 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoprotein to supply fatty acids, and its deficiency leads to hypertriglyceridemia, thereby inducing metabolic syndrome (MetSyn).
|
31234537 |
2019 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.
|
26370976 |
2015 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
LPL may influence atherosclerosis risk through pleiotropic effects on each aspect of the metabolic syndrome.
|
16755277 |
2007 |