LPL, lipoprotein lipase, 4023

N. diseases: 290; N. variants: 116
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 AlteredExpression disease BEFREE This appears to be the first reported genetic association with the insulin-resistance syndrome and may reflect genotype specific differences in the regulation of lipoprotein lipase by insulin. 7905375 1993
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE This presumed impaired effect of insulin on LPL postprandially could be an important contributor to the atherogenic dyslipidaemia described in insulin resistance syndrome. 11895454 2002
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE This study shows that carrier status of one defective lipoprotein-lipase allele is associated with impaired insulin sensitivity, an atherogenic lipoprotein profile and other characteristics of the metabolic syndrome, which are risk factors for atherosclerotic vascular disease. 11914743 2002
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE This haplotype-based genetic analysis provides compelling evidence that variation in the LPL gene plays a role in determining insulin resistance in this ethnic group with a high prevalence of the insulin resistance syndrome. 14693718 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE Together, these results indicate a clear role for PPARbeta in regulating levels of serum triglycerides in mice on a high fat Western diet by modulating both VLDL production and LPL-mediated catabolism of VLDL-triglycerides and also suggest a potential therapeutic role for PPARbeta in the improvement of serum lipids in the setting of metabolic syndrome. 15001574 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 AlteredExpression disease BEFREE The fourth most common haplotype based on 19 SNPs (haplotype 19-4) was associated with increased LPL activity as well as multiple phenotypes related to the metabolic syndrome. 15928243 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE The present study has shown that the S1 allele of APOC3 SstI polymorphism and the H- allele of LPL HindIII polymorphism might have a small effect on apoB levels in the Central European Caucasian population with dyslipidemia of metabolic syndrome. 16343038 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE LPL may influence atherosclerosis risk through pleiotropic effects on each aspect of the metabolic syndrome. 16755277 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 AlteredExpression disease BEFREE These results show that decreased expression of LPL possibly causes the insulin resistance, in addition to hypertriglyceridemia, in metabolic syndrome. 16941273 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE Haplotype 2 was identified as a new risk haplotype, suggesting the complex nature of LPL's effect on features of the insulin resistance syndrome. 17032721 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks. 17555736 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE Logistic regression analysis after adjustment for age, sex, adiponectin and S447X polymorphism demonstrated that LPL mass was inversely associated with CHD in men and both genders (p=0.02), with hypertension confined to women (p=0.04) and with MS likelihood in both genders combined and women [odds ratio 1.51 (95% CI 1.14-2.00) for halving the likelihood]. 19191728 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE We assessed lipid levels and the frequencies of the cholesteryl ester transfer protein (CETP) Taq-1 B, lipoprotein lipase (LPL)S447X, -93 T/G, apolipoprotein B (APO B) 96bp ins/del, lipoprotein(a) (LP[a]) pentanucleotide repeat, and apolipoprotein E (APO) E epsilon 2/3/4 polymorphisms in relation to the metabolic syndrome using both National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) definitions. 19642912 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease GWASDB A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE Plasma fatty acid composition, plasma lipid concentrations and LPL SNPs were determined in 452 subjects with the MetS in the European LIPGENE human study and were repeated in 1754 subjects from the LIPGENE-SU.VI.MAX Study. 21840003 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE This was the first study this kind to show an association between LPL and large VLDL particle size within the MetS, a pattern associated with higher IR. 21854610 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE LPL mass was significantly lower in patients with PvuII and HindIII mutant alleles (P2 and H2) and decreased as the number of MetSyn components increased in all PvuII and HindIII haplotypes. 23927945 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013). 24200052 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE A novel African American-specific variant, rs12721054/APOC1, and rs10096633/LPL are associated with ≥3 MetS components. 25023634 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features. 26370976 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE Finally, we replicated the LPL and CETP loci previously found to be associated with MetS in Europeans. 26507551 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Therapeutic disease RGD Gly in MS rats decreased body weight, intra-abdominal adipose tissue, adipocyte hypertrophy, blood pressure, triglycerides, insulin, HOMA-IR index, leptin, total fatty acids, non-esterified fatty acids and LPL activity. 26996629 2016