The levels of miR-144 and miR-212 associated positively with ulceration (<i>p</i> = 0.012 and <i>p</i> = 0.027, respectively) while miR-510 levels associated positively with lymph node metastases at the time of diagnosis (<i>p</i> = 0.004).
Clinical association analysis indicated that low expression of miR‑212 was prominently associated with large tumor size, advanced tumor, nodes, metastasis stage and lymph node metastasis.
In addition, we demonstrated that miR-212 downrwegulation in thyroid cancer tissues was negatively associated with lymph node metastasis and advanced clinical stage.
Our clinical analysis revealed that the reduced miR-212 expression was significantly correlated with poor prognostic features including positive lymph node metastasis and advanced tumor-node-metastasis (TNM) stage.