|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the levels of miR-27a/b increased in the serum of patients with type 2 diabetes.
|
31526292 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
Biomarker
|
disease |
CTD_human |
"Serum microRNA signatures as ""liquid biopsies"" for interrogating hepatotoxic mechanisms and liver pathogenesis in human."
|
28545106 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Our study shows that rs895819 in hsa-mir-27a is associated with T2DM susceptibility and that the C allele conveyed a protective role against T2DM.
|
27300034 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people.
|
25673459 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The focus of this study, therefore, is the association of T2DM with five SNPs (rs895819 in miR-27a, rs531564 in miR-124a, rs11888095 in miR-128a, rs3820455 in miR-194a and rs2910164 in miR-146a) located in five miRNAs in a Han Chinese population.
|
26640407 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes.
|
24682535 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms were associated with T2DM susceptibility: in particular, the G allele of rs895819 in hsa-mir-27a has shown a significantly protective effect (OR = 0.58 and P = 0.008), while the G allele of rs531564 in hsa-mir-124a appears to be a risk allele (OR = 2.15, P = 0.008).
|
23532299 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.370 |
Biomarker
|
disease |
BEFREE |
More recently, studies have identified important roles for miR-27 in angiogenesis, adipogenesis, inflammation, lipid metabolism, oxidative stress, insulin resistance and type 2 diabetes, etc.
|
22307089 |
2012 |
|
Pancreatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
|
27840954 |
2016 |
|
Myocardial Reperfusion Injury
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol.
|
22050707 |
2012 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-23a-27a-24-2 is located in the human chromosome 9q22, forming three mature miRNAs: miR-23a, miR27a, and miR-24, which are expressed abnormally in many malignant tumors.
|
31192453 |
2020 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The overall analysis showed the miR-27a rs895819 was not associated with cancer susceptibility in all models (dominant model: OR=1.02, 95% CI:0.94-1.10, p=0.632; recessive model :OR=1.05, 95% CI: 0.92-1.76, p=0.474; homozygote model: OR=1.06, 95% CI: 0.91-1.23, p=0.439; heterozygote model: OR=1.00, 95% CI: 0.93-1.08, p=0.934; and allele model: OR=1.02, 95% CI: 0.96-1.09, p=0.486).
|
31838252 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, the effect of miR-27a on tumorigenesis and microvessel density (MVD) was analysed after xenograft tumour inoculation in nude mice.
|
31724333 |
2020 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Finally, the effect of miR-27a on tumorigenesis and microvessel density (MVD) was analysed after xenograft tumour inoculation in nude mice.
|
31724333 |
2020 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The role of miR-27a-5p in EC migration and invasion was further investigated via transfection with miR-27a-5p mimics or inhibitor in Ishikawa and HEC-1A EC cell lines.
|
31710594 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The overall analysis showed the miR-27a rs895819 was not associated with cancer susceptibility in all models (dominant model: OR=1.02, 95% CI:0.94-1.10, p=0.632; recessive model :OR=1.05, 95% CI: 0.92-1.76, p=0.474; homozygote model: OR=1.06, 95% CI: 0.91-1.23, p=0.439; heterozygote model: OR=1.00, 95% CI: 0.93-1.08, p=0.934; and allele model: OR=1.02, 95% CI: 0.96-1.09, p=0.486).
|
31838252 |
2020 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-27a (miR-27a) is a small non-coding RNA, shown to play a role in multiple cancers, including the regulation of ERα expression in breast cancer.
|
30415143 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion:</b> Detection of miR 27a expression may serve as a potential sensitive minimally invasive molecular marker for early detection of primary BC.
|
31145011 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous (A/G allele) as well as homozygous (G/G allele) variants were found in mir-27a gene in screened BC patients.
|
30767608 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of microRNA-27a-3p inhibits non-small lung cancer cell proliferation but promotes cell apoptosis.
|
31319766 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Accumulating evidence reveals that microRNA 27a (miR 27a) is implicated in the pathogenesis of cancer.
|
31145011 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, even though miR-27a has been reported in many cancers, the mechanism and signal pathways of miR-27 in oncogenesis, invasion, and metastasis are still obscure.
|
31572683 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The miR-27a could be an oncogene or a tumor suppressor in several types of cancer, including colon cancer, pancreatic cancer, breast cancer, bladder cancer and hepatocellular carcinoma.
|
31258791 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The diagnostic sensitivity, specificity and accordance rates of positive miR-27a and miR-31 expression in colorectal cancer were recorded.
|
31452786 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that three miRNAs in the miR-23a∼27a∼24 cluster, miR-23a, miR-27a and miR-24, are the most upregulated miRNA cluster in colorectal cancer (CRC) under hypoxia.
|
30393198 |
2019 |