Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
CLINGEN |
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
|
11779503 |
2001 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
CLINGEN |
Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway.
|
19224541 |
2009 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
CLINGEN |
SMAD proteins control DROSHA-mediated microRNA maturation.
|
18548003 |
2008 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
CLINGEN |
SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections.
|
26247899 |
2015 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
CLINGEN |
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.
|
8980228 |
1996 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.500 |
Biomarker
|
disease |
CLINGEN |
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
|
9311995 |
1997 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic mutations can occur in the precursors, and the combined prevalence of SMAD4, SMAD2, and SMAD3 mutations was seen in up to 50% of CRCs.
|
28601657 |
2017 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
RT-PCR sequencing analysis of the HL60 Smad5 remaining allele ruled out the functional inactivation of the gene analogous to that occurring in the Smad5 homologs DPC4 and Smad2 in cases of pancreatic and colorectal cancers.
|
9264367 |
1997 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Other members of the SMAD family are excellent candidates for JPS, especially SMAD2 (which, like SMAD4, is mutated somatically in colorectal cancers), SMAD3 (which causes colorectal cancer when "knocked out" in mice), SMAD5, and SMAD1.
|
10446110 |
1999 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Residing in this region are the Madh2 and Madh4 genes, which have both been implicated in human colorectal cancer.
|
12584607 |
2003 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that the carcinogenetic pathways of protruding and superficial depressed colorectal cancers are different, and that alterations of tumor suppressor gene(s) located on 18q21 other than Smad2, Smad4 and DCC might be associated with most superficial depressed colorectal cancers.
|
10665650 |
1999 |
Colorectal Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Importantly, studies of patient samples indicate that expression of PDK4 and phosphorylation of Smad2, an indicator of TGFβ pathway activation, show a strong correlation and that both positively associate with chemoresistance in colorectal cancer.
|
27330076 |
2016 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.
|
19531654 |
2009 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MADR2 is a tumor suppressor and that mutations acquired in colorectal carcinomas may function to disrupt TGFbeta signaling.
|
8752209 |
1996 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Colorectal cancers (CRCs) frequently harbor somatic mutations in the pathway members TGFBR2 and SMAD4, but to what extent mutations in SMAD2 or SMAD3 contribute to tumorigenesis is unclear.
|
23139211 |
2013 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The vast majority (93.8%; 95% CI: 92%-96%) of colorectal cancers expressed phosphorylated Smad2, indicating the ability of the tumors to survive and proliferate within a microenvironment that contains bioactive TGF-beta.
|
12967141 |
2003 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Ten gastric and 9 colorectal PDECs, 9 gastric WDECs, and 12 colorectal carcinomas (CRCs) were analyzed for loss of heterozygosity (LOH) at 11q13 (MEN1), 17p13.1 (p53), 3p14.2 (FHIT), 3p21.3 (RASSF1A), and 18q23 (DCC/DPC4/Smad2), and for immunohistochemical expression of p53, FHIT, Rb, and p16.
|
12973852 |
2003 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
DPC4 and MADR2/JV18-1 are recently demonstrated to be altered in pancreatic and colorectal cancers, respectively.
|
9288786 |
1997 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Colorectal Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
SMAD2 was phosphorylated in most MSI-H CRC tissues (strong detection in 44% and weak detection in 34% of MSI-H tumors).
|
25736321 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The MUTYH mutational signature reflecting persistent 8-oxoG:A mismatches occurs frequently in the APC, KRAS, PIK3CA, FAT4, TP53, FAT1, AMER1, KDM6A, SMAD4 and SMAD2 genes that are associated with CRC.
|
28551381 |
2017 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show that hsa-miR-140-5p directly targets Smad2 and overexpression of hsa-miR-140-5p in CRC cell lines decreases Smad2 expression levels, leading decreased cell invasion and proliferation, and increasing cell cycle arrest.
|
25980495 |
2015 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Alterations in transforming growth factor-beta signaling, due to a decrease in Smad2 and especially Smad4 expression, has primarily been reported in pancreatic and colorectal cancers, although loss of the chromosomal region 18q21.1, containing the loci of Smad2 and Smad4, is among the most frequent molecular alterations in cervical cancer.
|
18425078 |
2008 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Somatic alterations of the DPC4 and Madr2 genes in colorectal cancers and relationship to metastasis.
|
11172591 |
2001 |