|
Cleft Palate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SMAD2 overexpression rescues the TGF-β3 null mutant mice cleft palate by increased apoptosis.
|
31677482 |
2020 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, inhibiting Smad2/3 phosphorylation with ponatinib or SIS3 also significantly reduced seizure severity, alongside reducing GFAP/CS56 immunoreactivity.
|
31664678 |
2020 |
|
Polymyositis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TLR9 and Smad2 were up-regulated in lung tissue of PM group than control group, and NETs further increased TLR9 and Smad2 expressions.
|
31821687 |
2020 |
|
Skin callus
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Meanwhile, IFT80 deletion downregulated the TGF-β signaling pathway by inhibiting the expression of TGF-βI, TGF-βR, and phosphorylation of Smad2/3 in the fracture callus.
|
31643106 |
2020 |
|
Cleft palate, isolated
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SMAD2 overexpression rescues the TGF-β3 null mutant mice cleft palate by increased apoptosis.
|
31677482 |
2020 |
|
Uranostaphyloschisis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SMAD2 overexpression rescues the TGF-β3 null mutant mice cleft palate by increased apoptosis.
|
31677482 |
2020 |
|
Ulcerative Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Four SNPs (rs13381619, rs9955626, rs1792658, and rs1792671) within SMAD2, one SNP within SMAD3 (rs41473580" genes_norm="4087;4088;4089;4092">rs41473580), two SNPs within SMAD4 (rs7229678 and rs9304407), and one SNP within SMAD7 (rs12956924) were significantly associated with susceptibility only to UC. rs13381619 within SMAD2, rs4147358 within SMAD3, rs9304407 within SMAD4, and rs12956924 within SMAD7 exhibited the strongest association (p < 0.001, p = 0.021, p = 0.005, and p = 0.001, respectively).
|
30653987 |
2019 |
|
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aims to evaluate the efficacy of lysyl oxidase (LOX) inhibition in regulating rat myocardial fibrosis and chronic heart failure (CHF) and to validate the regulation of LOX by TGF-β1/Smad2/3 signaling in this process.
|
31317653 |
2019 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Results</b>: Results show that disruption of TGF-β type II receptor suppressed Smad2/3 activation and attenuated renal injury in cisplatin nephropathy.
|
31754396 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, we evaluated whether Smad2 could serve as a therapeutic target in both cisplatin- and ischemic/reperfusion (I/R)-induced AKI mouse models by silencing Smad2 <i>in vivo</i>.
|
31754396 |
2019 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor.
|
31035970 |
2019 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Role of TGF-Beta1/SMAD2/3 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 50/10 Oxygen-Induced Retinopathy.
|
31240212 |
2019 |
|
Thromboangiitis Obliterans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both PH20 and HMW-HA upregulated CD44 expression and inhibited SMAD2/3 expression in the TAO group, and the inhibitory effects were partially reversed by CD44 blockage.
|
30947333 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression of miR-153 in patients with NPC was markedly decreased compared with that in paracarcinoma tissue. miR-153 upregulation observably decreased cell viability, induced apoptosis, increased caspase-3 and -9 activity, and increased the B-cell lymphoma 2 (Bcl-2)-associated X protein/Bcl-2 protein expression ratio in 13-9B cells. miR-153 upregulation also suppressed transforming growth factor-β<sub>2</sub> (TGF-β<sub>2</sub>) and Smad2 protein expression in 13-9B cells.
|
30655812 |
2019 |
|
Pancreatitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that piperine treatment ameliorates pancreatic fibrosis by inhibiting TGF‑β/SMAD2/3 signaling during CP.
|
31485676 |
2019 |
|
Adenocarcinoma of rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TIPE2 overexpression decreased autophagy by reducing the expression levels of p-Smad2, p-Smad3, and transforming growth factor-beta (TGF-β) in rectal adenocarcinoma cells, however, TIPE2 knockdown showed opposite effects.
|
30637920 |
2019 |
|
Coronary Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a mouse model of non-reperfused myocardial infarction, Smad2 activation in infarct myofibroblasts peaked 7 days after coronary occlusion.
|
31085202 |
2019 |
|
Uterine Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endometrial hyperplasia worsened with age, and all <i>Smad2/3</i> cKO mice ultimately developed bulky endometrioid-type uterine cancers with 100% mortality by 8 months of age.
|
30651315 |
2019 |
|
Cartilage-hair hypoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of note, we observed disturbances in this viperin-CXCL10-TGF-β/SMAD2/3 axis in CHH chondrocytic cells.
|
30718282 |
2019 |
|
Arthritis of knee
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of SMAD2 reversed the inhibitory effects on proliferation and promotion effects on apoptosis induced by miR-15a in knee arthritis chondrocytes.
|
31366242 |
2019 |
|
Linear Scleroderma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fibroblasts from LM lesions showed increased migration, proliferation, altered collagen processing, and abnormally high basal levels of phosphorylated SMAD2, thereby rendering them less responsive to transforming growth factor (TGF)-β1 and reducing the degree of myofibroblast differentiation, which is a key component of the wound-healing and scarring process in normal skin.
|
30367460 |
2019 |
|
Dissection of aorta
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found significantly increased expression of phospho-Smad2/3 and phospho-ERK in AD tissues and downregulated expression of miR143 and miR145 in AD tissues.
|
30787994 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CTRP9 markedly ameliorated macrophage infiltration and attenuated the inflammatory responses by downregulating interleukin-1β and interleukin-6, and upregulating interleukin-10, in 3 days post-MI; depressed left atrial fibrosis by decreasing the expressions of collagen types I and III, α-SMA, and transforming growth factor β1 in 7 days post-MI possibly through depressing the Toll-like receptor 4/nuclear factor-κB and Smad2/3 signaling pathways.
|
31623508 |
2019 |
|
Squamous cell carcinoma of mouth
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nevertheless, canonical p-Smad2 was largely repressed in OSCC tumor tissues, suggesting that the activin A-mediated noncanonical pathway is essential for the carcinogenesis of OSCC.
|
30914776 |
2019 |
|
Liver regeneration disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Suppression of cell-cycle progression via TGF-β-SMAD2/3 signaling pathway may be a key mechanism by which GDF11 inhibits liver regeneration.
|
31654062 |
2019 |