|
Acromicric Dysplasia
|
0.300 |
Biomarker
|
disease |
CTD_human |
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation.
|
18677313 |
2008 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Smad2/3 Linker Phosphorylation Is a Possible Marker of Pancreatic Stem/Progenitor Cells in the Regenerative Phase of Acute Pancreatitis.
|
28099259 |
2018 |
|
Adenocarcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
The presence of chromosome 18q loss and DPC4 mutations in appendiceal adenocarcinomas suggests involvement of DPC4 and nearby genes on chromosome 18q (DCC and/or JV-18) in the pathogenesis of appendiceal adenocarcinomas.
|
14647445 |
2004 |
|
Adenocarcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
The calculated ratio of the hsMAD2 protein in cancer tissue (C) to that in corresponding normal tissue (N) (C / N ratio) was significantly higher in patients with well differentiated adenocarcinoma (P = 0.0274) or with synchronous liver metastasis (P = 0.0025).
|
11572763 |
2001 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MDM2 promotes epithelial-mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma.
|
30988629 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
The phosphorylation of USP2a and SMAD2 is positively correlated in human tumor biopsies, and USP2a is hyper-phosphorylated in lung adenocarcinomas with lymph node invasion.
|
29490279 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we showed that knocking down FUT2 in LUAD cell lines increased the expression of E-cadherin and reduced the expression of Vimentin, N-cadherin, TβRII, p-Smad2, p-Smad3 and Snail, which were the makers of EMT.
|
30031128 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Overexpression of miR‑361‑5p plays an oncogenic role in human lung adenocarcinoma through the regulation of SMAD2.
|
30365047 |
2019 |
|
Adenocarcinoma of rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TIPE2 overexpression decreased autophagy by reducing the expression levels of p-Smad2, p-Smad3, and transforming growth factor-beta (TGF-β) in rectal adenocarcinoma cells, however, TIPE2 knockdown showed opposite effects.
|
30637920 |
2019 |
|
Adrenal Gland Pheochromocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that proliferating pancreatic cancer cells (PCCs) from human PDAC patients and multiple murine models of PDAC (mPDAC) often exhibit abundant levels of phosphorylated retinoblastoma 1 (RB) and Smad2.
|
24334458 |
2014 |
|
Adult Angiosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Angiosarcoma of bone showed highly active TGF-β signaling with immunoreactivity for phospho-Smad2 and PAI-1.
|
23599148 |
2013 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.
|
23297089 |
2013 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In this study, we investigate whether nuclear SMAD2 can restrain the proliferation of glioblastoma.
|
25832460 |
2015 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Identification of novel LncRNA targeting Smad2/PKCα signal pathway to negatively regulate malignant progression of glioblastoma.
|
31603255 |
2020 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.
|
21406405 |
2011 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
MiR-145 inhibits EGF-induced epithelial-to-mesenchymal transition via targeting Smad2 in human glioblastoma.
|
31114250 |
2019 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, GDF11 has a tumor suppressor role in liver cancer, exerts its effects through Smad2/3 signaling and may serve as a novel tumor marker in liver cancer diagnosis.
|
29545874 |
2018 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
1) CHI3L1 promoted cancer cell proliferation by regulating cell cycles; 2) CHI3L1 promoted cancer cell invasion and metastasis; 3) CHI3L1 regulate liver cancer potentially by regulating the TGF-β signaling pathways; 4) CHI3L1 has direct kinase activities or activate kinase to phosphorylate SMAD2, SMAD3.
|
30301907 |
2018 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 34 leukemia and lymphoma samples (17 clinical samples and 17 cell lines) were analyzed for mutations of the Smad2 gene by reverse transcriptase-polymerase chain reaction single strand conformation polymorphism (RT-PCR-SSCP) analysis.
|
9436926 |
1998 |
|
After-cataract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells.
|
24911914 |
2015 |
|
Age at menarche
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Alcohol abuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis on human ALC and HC indicated a high similarity with canine samples in TGF-beta1 expression and Smad2/3 phosphorylation.
|
16842329 |
2006 |
|
Allergic rhinitis (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, phosphorylated Smad2 expression increased in nasal epithelial cells in patients with allergic rhinitis.
|
20495338 |
2010 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling.
|
28366226 |
2017 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that blockade of TGF-beta-Smad2/3 signaling in peripheral macrophages represents a new therapeutic target for Alzheimer's disease.
|
18516051 |
2008 |