|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH.
|
29682587 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The immune response to myelin basic protein and pathological changes of demyelination in SAE suggest that this disease is the human homologue of experimental autoimmune encephalomyelitis (EAE).
|
10319881 |
1999 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
|
19300513 |
2009 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since histone deacetylase (HDAC) inhibitors have been previously shown to improve neurological disability, we also show that treatment with trichostatin A (a HDAC inhibitor) improves the NDS of EAE mice but does not change MBP acetylation.
|
29111742 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
During the acute EAE phase (7-20 days after immunization), catalytic antibodies efficiently hydrolysing myelin basic protein (MBP), MOG and DNA are produced with parallel suppression of antibodies hydrolysing histones.
|
30265424 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Repertoire analyses of activated T-cell populations specific for myelin basic protein, peptides of which cause experimental allergic encephalomyelitis in rats and mice, indicate a very limited utilization of homologous V alpha and V beta genes in both species.
|
7691066 |
1993 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using this approach, we demonstrate that antigen persistence is a dominant factor governing the elicitation of tolerance in the model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), induced by immunizing B10.PL mice with the N-terminal epitope of myelin basic protein.
|
27236506 |
2016 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DHEA-S treatment also preserved myelin basic protein immunoreactivity and reduced axonal loss in animals with EAE, relative to vehicle-treated EAE animals.
|
28707358 |
2017 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment.
|
29224959 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then monitored the thickness of the retinal layers in different EAE models: in wild-type (WT) C57Bl/6J mice immunized with myelin oligodendrocyte glycoprotein peptide (MOG<sub>35-55</sub>) or with bovine myelin basic protein (MBP), in TCR<sup>2D2</sup> mice immunized with MOG<sub>35-55</sub>, and in SJL/J mice immunized with myelin proteolipid lipoprotein (PLP<sub>139-151</sub>).
|
31684959 |
2019 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aspirin reduced the development of EAE driven by myelin basic protein (MBP)-specific T cells and the associated perivascular cuffing, inflammation, and demyelination.
|
30482850 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, cyclo(87-99)[Arg<sup>91</sup>, Ala<sup>96</sup>]MBP<sub>87-99</sub> was highly effective in preventing the onset and development of clinical symptoms and spinal cord pathology and providing lasting protection against EAE induction.
|
29385090 |
2018 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.
|
2409602 |
1985 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(2) In both diseases, the autoimmune T cells are clonally heterogeneous but recognize only a limited number of epitopes on the autoantigen (acetylcholine receptor in MG; myelin basic protein in EAE).
|
2662895 |
1989 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This beneficial effect of LF 15-0195 on EAE does not result from the deletion of MBP-specific Vbeta8.2 encephalitogenic T cells.
|
16393967 |
2006 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The T line cells used to induce adoptive EAE were myelin basic protein (MBP)-specific, constitutively contained mRNA for Kv1.3. and expressed Kv1.3.
|
11145670 |
2001 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic protein (MBP).
|
1706524 |
1991 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DAB(389)IL-2 in vitro treatment suppressed cytotoxicity of MBP-activated T cells from rats with EAE against oligodendrocytes in culture by 66%.
|
23872438 |
2014 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progesterone given prior to EAE induction attenuated the clinical scores of the disease, slightly delayed disease onset and decreased demyelination foci, according to luxol fast blue staining (LFB), myelin basic protein (MBP) and proteolipid protein (PLP) and mRNA expression.
|
18667803 |
2008 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data show that upon induction of EAE in HLA-DR4 transgenic mice with the immunodominant HLA-DR4-restricted MOG peptide 97-108 (MOG(97-108); TCFFRDHSYQEE), the T cell response diversifies over time to MOG(181-200) (core: MOG(183-191); FVIVPVLGP) and MBP.
|
15093552 |
2004 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experimental allergic encephalomyelitis (EAE) is a T cell mediated model of demyelinating disease that develops as a result of an autoimmune response to the myelin structural antigen, myelin basic protein (MBP).
|
1718484 |
1991 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Induction of EAE caused a significant decrease of myelin basic protein expression in the hindbrain of disease affected WT mice in comparison to Cpt1a P479L mice.
|
31527712 |
2019 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consistently, histopathological studies coupled with microscope-cellSens quantification and RT-qPCR analyzes showed that XBD173 prevented demyelination by restoring normal protein and mRNA levels of myelin basic protein that was significantly repressed in PLP-EAE mice spinal cord and brain.
|
28899788 |
2017 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that subcutaneously administered myelin basic protein (MBP)-pulsed CD11c+ bone marrow-derived dendritic cells (BMDC) were as effective at inducing EAE as subcutaneously administered MBP plus CFA.
|
27488372 |
2017 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transgenic mice with targeted overexpression of dominant-negative RAGE in CD4+ T cells were resistant to MBP-induced EAE.
|
12598893 |
2003 |