|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.
|
2409602 |
1985 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of the humoral phase of the immune response in development of T cell-mediated experimental allergic encephalomyelitis (EAE) had not been clearly defined previously even though studies of the myelin basic protein (MBP) molecule had demonstrated the presence not only of T cell but also B cell epitopes capable of inducing cell-mediated immunity and antibody formation.
|
2464069 |
1988 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(2) In both diseases, the autoimmune T cells are clonally heterogeneous but recognize only a limited number of epitopes on the autoantigen (acetylcholine receptor in MG; myelin basic protein in EAE).
|
2662895 |
1989 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic protein (MBP).
|
1706524 |
1991 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experimental allergic encephalomyelitis (EAE) is a T cell mediated model of demyelinating disease that develops as a result of an autoimmune response to the myelin structural antigen, myelin basic protein (MBP).
|
1718484 |
1991 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Repertoire analyses of activated T-cell populations specific for myelin basic protein, peptides of which cause experimental allergic encephalomyelitis in rats and mice, indicate a very limited utilization of homologous V alpha and V beta genes in both species.
|
7691066 |
1993 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The deduced amino-acid sequence of this VDJ rearrangement, Leu-Arg-Gly, has also been described in rat T cells cloned from experimental allergic encephalomyelitis lesions, which are specific for MBP peptide 87-99 (ref.2).
|
7680433 |
1993 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myelin basic protein-specific T cells, which induce experimental autoimmune encephalomyelitis in many animal strains, may be important in the pathogenesis of multiple sclerosis.
|
7510746 |
1994 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myelin basic protein in experimental allergic encephalomyelitis is not affected at the posttranslational level: implications for demyelinating disease.
|
8739153 |
1996 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have determined that mice vaccinated with recombinant viruses encoding an encephalitogenic region of MBP were protected from EAE.
|
8632058 |
1996 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunization with MBP peptide stimulates the transgenic T cells to produce Th1 cytokines; however, the activated T cells do not accumulate in the central nervous system and induce EAE unless pertussis toxin is also administered.
|
9200491 |
1997 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The immune response to myelin basic protein and pathological changes of demyelination in SAE suggest that this disease is the human homologue of experimental autoimmune encephalomyelitis (EAE).
|
10319881 |
1999 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Treatment with a DNA vaccine encoding myelin basic protein peptide 68-85 and containing three ISS of 5'-AACGTT-3' sequence suppressed clinical signs of EAE, while a corresponding DNA vaccine without such ISS had no effect.
|
10528174 |
1999 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It can also amelioriate the development of experimental allergic encephalomyelitis (EAE) without the usual side effects of IFN therapy in mice autoimmunized with myelin basic protein.
|
10638702 |
1999 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Though many lines of evidence support the importance of myelin basic protein (MBP) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), its role in multiple sclerosis (MS) is still debated as well as the significance of epitope spreading in disease progression.
|
10871786 |
2000 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The T line cells used to induce adoptive EAE were myelin basic protein (MBP)-specific, constitutively contained mRNA for Kv1.3. and expressed Kv1.3.
|
11145670 |
2001 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Systemic administration of hmTAP not only suppressed and treated experimental autoimmune encephalomyelitis (EAE) initiated by autoreactivity to a PLP epitope, but also abrogated complex EAE transferred by multispecific line T cells reactive against encephalitogenic epitopes of MBP, PLP, and MOG.
|
12093891 |
2002 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transgenic mice with targeted overexpression of dominant-negative RAGE in CD4+ T cells were resistant to MBP-induced EAE.
|
12598893 |
2003 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data show that upon induction of EAE in HLA-DR4 transgenic mice with the immunodominant HLA-DR4-restricted MOG peptide 97-108 (MOG(97-108); TCFFRDHSYQEE), the T cell response diversifies over time to MOG(181-200) (core: MOG(183-191); FVIVPVLGP) and MBP.
|
15093552 |
2004 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, MBP-87-99, which can induce EAE in double-Tg mice expressing both HLA-DR2 and a human MBP-specific TCR, was completely non-encephalitogenic in HLA-DR2-Tg mice lacking the human TCR transgene.
|
15114658 |
2004 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This beneficial effect of LF 15-0195 on EAE does not result from the deletion of MBP-specific Vbeta8.2 encephalitogenic T cells.
|
16393967 |
2006 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using experimental autoimmune encephalomyelitis (EAE) as a model, we previously reported that retrovirally transduced B cells expressing myelin basic protein (MBP), MBP Ac1-11, or myelin oligodendrocyte glycoprotein p35-55 induced tolerance and reduced symptoms.
|
16219491 |
2006 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progesterone given prior to EAE induction attenuated the clinical scores of the disease, slightly delayed disease onset and decreased demyelination foci, according to luxol fast blue staining (LFB), myelin basic protein (MBP) and proteolipid protein (PLP) and mRNA expression.
|
18667803 |
2008 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
|
19300513 |
2009 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study addressed whether a fusion protein containing rat IFN-beta and the encephalitogenic 73-87 determinant of myelin basic protein (i.e., the neuroantigen, or NAg) could prevent or treat experimental autoimmune encephalomyelitis (EAE) in Lewis rats.
|
19380780 |
2009 |