|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(2) In both diseases, the autoimmune T cells are clonally heterogeneous but recognize only a limited number of epitopes on the autoantigen (acetylcholine receptor in MG; myelin basic protein in EAE).
|
2662895 |
1989 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MBP-PLP fusion protein (MP4)-induced experimental autoimmune encephalomyelitis (EAE) is a model for multiple sclerosis (MS) that encompasses both a time-dependent attack on central nervous system (CNS) regions and a B cell component, mirroring important features of human multiple sclerosis.
|
20078558 |
2009 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myelin basic protein (MBP) is a major target of T cells in lesions of multiple sclerosis (MS) patients and its animal model, experimental autoimmune encephalomyelitis (EAE).
|
28889362 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myelin basic protein-specific T cells, which induce experimental autoimmune encephalomyelitis in many animal strains, may be important in the pathogenesis of multiple sclerosis.
|
7510746 |
1994 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myelin basic protein in experimental allergic encephalomyelitis is not affected at the posttranslational level: implications for demyelinating disease.
|
8739153 |
1996 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment.
|
29224959 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, the magnitudes of myelin basic protein (MBP)-induced rise in the frequency of IFN-γ+ and IL-17+ CD8+ T cells (providing important help to neuroantigen-specific CD4+ T cells in EAE models characterized by clinically mild disease) were greater in dLN cell cultures from aged AO rats.
|
29128575 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aspirin reduced the development of EAE driven by myelin basic protein (MBP)-specific T cells and the associated perivascular cuffing, inflammation, and demyelination.
|
30482850 |
2018 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consistently, histopathological studies coupled with microscope-cellSens quantification and RT-qPCR analyzes showed that XBD173 prevented demyelination by restoring normal protein and mRNA levels of myelin basic protein that was significantly repressed in PLP-EAE mice spinal cord and brain.
|
28899788 |
2017 |
|
Encephalomyelitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DAB(389)IL-2 in vitro treatment suppressed cytotoxicity of MBP-activated T cells from rats with EAE against oligodendrocytes in culture by 66%.
|
23872438 |
2014 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model.
|
28425447 |
2017 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DHEA-S treatment also preserved myelin basic protein immunoreactivity and reduced axonal loss in animals with EAE, relative to vehicle-treated EAE animals.
|
28707358 |
2017 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
During the acute EAE phase (7-20 days after immunization), catalytic antibodies efficiently hydrolysing myelin basic protein (MBP), MOG and DNA are produced with parallel suppression of antibodies hydrolysing histones.
|
30265424 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experimental allergic encephalomyelitis (EAE) is a T cell mediated model of demyelinating disease that develops as a result of an autoimmune response to the myelin structural antigen, myelin basic protein (MBP).
|
1718484 |
1991 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunization with MBP peptide stimulates the transgenic T cells to produce Th1 cytokines; however, the activated T cells do not accumulate in the central nervous system and induce EAE unless pertussis toxin is also administered.
|
9200491 |
1997 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, MBP-87-99, which can induce EAE in double-Tg mice expressing both HLA-DR2 and a human MBP-specific TCR, was completely non-encephalitogenic in HLA-DR2-Tg mice lacking the human TCR transgene.
|
15114658 |
2004 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, cyclo(87-99)[Arg<sup>91</sup>, Ala<sup>96</sup>]MBP<sub>87-99</sub> was highly effective in preventing the onset and development of clinical symptoms and spinal cord pathology and providing lasting protection against EAE induction.
|
29385090 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, Lewis rats immunized with myelin basic protein (MBP) 82-99 or MBP68-86 exhibited clinical signs of EAE and inflammatory infiltrates throughout CNS.
|
24388990 |
2014 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that subcutaneously administered myelin basic protein (MBP)-pulsed CD11c+ bone marrow-derived dendritic cells (BMDC) were as effective at inducing EAE as subcutaneously administered MBP plus CFA.
|
27488372 |
2017 |
|
Encephalomyelitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Induction of EAE caused a significant decrease of myelin basic protein expression in the hindbrain of disease affected WT mice in comparison to Cpt1a P479L mice.
|
31527712 |
2019 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It can also amelioriate the development of experimental allergic encephalomyelitis (EAE) without the usual side effects of IFN therapy in mice autoimmunized with myelin basic protein.
|
10638702 |
1999 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH.
|
29682587 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
|
19300513 |
2009 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we showed that myelin-reactive autoantibodies from patients with multiple sclerosis (MS) and mice with experimental autoimmune encephalomyelitis (EAE) exhibit the ability to recognize and hydrolyse distinct epitopes within myelin basic protein (MBP).
|
30139963 |
2018 |
|
Encephalomyelitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Progesterone given prior to EAE induction attenuated the clinical scores of the disease, slightly delayed disease onset and decreased demyelination foci, according to luxol fast blue staining (LFB), myelin basic protein (MBP) and proteolipid protein (PLP) and mRNA expression.
|
18667803 |
2008 |