Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The melanocortin-4 receptor (MC4-R) regulates food intake and possibly energy expenditure, and the inactivation of the MC4-R by gene targeting results in obesity, a phenotype strongly associated with Type II (non-insulin-dependent) diabetes mellitus.
|
11692184 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Likewise, its homologous MC4R in human obesity, MC3R gene is also a good candidate for genetic susceptibility to glucose intolerance and T2DM.
|
11397906 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prospectively, we demonstrated that each FTO and MC4R risk allele increased obesity and T2D incidences by 24% (P = 0.02) and 21% (P = 0.02), respectively.
|
19255736 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals.
|
19073769 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Common variants near melanocortin receptor 4 (MC4R) have been related to fatness and type 2 diabetes.
|
19844209 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we evaluated the association of two variants (rs12970134 and rs4450508) near MC4R and a nonsynonymous (Gln241His) variant (rs3812316) in MLXIPL gene with type 2 diabetes (T2D) and obesity-related QTs in our case-control cohort (n = 1,528; 745 T2D cases and 783 controls) from a Sikh population from North India.
|
19680233 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association with type 2 diabetes (P<or=0.05), of whom the three first would stand correction for multiple testing: CDKN2A/B rs10811661, OR: 1.26 (1.12-1.43) P = 1.8*10(-4); CDKAL1 rs10946398, OR: 1.23 (1.09-1.39); P = 7.1*10(-4), and TCF7L2 rs7903146, OR: 1.61 (1.19-2.18) P = 2.3 * 10(-3).
|
20161779 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Since the report of the MC4R knockout mouse in 1997, the field has been searching for links between this genetic biomarker and human obesity and type 2 diabetes.
|
20462274 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The objective was to investigate the genetic markers related to obesity genes FTO and MC4R and the gene of type 2 diabetes mellitus TCF7L2 for their contribution to risk of stroke and transient ischemic attacks (TIA).
|
21921652 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These novel results suggest that the association of the FTO-rs9939609 and the MC4R-rs17782313 polymorphisms with type 2 diabetes depends on diet and that a high adherence to the MedDiet counteracts the genetic predisposition.
|
23130628 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Carrying a genetic variant in BCL11A, ADAMTS9, IGF2BP2, WFS1, CDKAL1, TP53INP1, CDKN2A/B, TCF7L2, KCNQ1, HNF1A, FTO, MC4R and GCK increased the risk of T2D when assessing the Moroccan and Tunisian samples together.
|
22463974 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood.
|
22106157 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All studies that evaluated the association of at least one of the two MC4R polymorphism(s) with type 2 diabetes were included in the study.
|
22869321 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of the 5 SNPs analyzed, POL1-nearby variant rs488846 [P=0.044], and MC4R-nearby variant rs1942872 [P=0.012] were associated with moderate risk of T2DM.
|
23727064 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry.
|
23457408 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of FTO rs9939609 and MC4R rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients.
|
23849767 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is no evidence supporting an association between variants in the fat mass- and obesity-associated and melanocortin 4 receptor, and a member of the potassium voltage-gated channels genes and type 2 diabetes in the Saudi population.
|
25501231 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
When body mass index and waist circumference were further adjusted, the association of MC4R with type 2 diabetes remained significant (P = 1.81×10(-2)) and that of GNPDA2 was attenuated (P = 1.26×10(-1)), suggesting the effect of the locus including GNPDA2 on type 2 diabetes may be mediated through obesity.
|
25093408 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.
|
24151814 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Six separate groups were identified.Individuals with a more modern birth year, an MC4R mutation, or in utero exposure to T2D were clustered in the two groups with high increasing and chronic overweight z-scores (P < 0.0001).
|
26308479 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Notable associations observed for genes previously identified at genome-wide significance in other populations included MC4R (Pgenotyped = 4.49x10-4) for BMI and IGF2BP2 Pimputed_1000G = 2.55x10-6) for T2D.
|
25760438 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genome-wide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, and BCAR1.
|
25951451 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The interaction between MC4R genes with dietary factors plays a significant role in the development of obesity or Type 2 diabetes phenotypes.
|
26666384 |
2016 |