Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.
|
24151814 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All studies that evaluated the association of at least one of the two MC4R polymorphism(s) with type 2 diabetes were included in the study.
|
22869321 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Carrying a genetic variant in BCL11A, ADAMTS9, IGF2BP2, WFS1, CDKAL1, TP53INP1, CDKN2A/B, TCF7L2, KCNQ1, HNF1A, FTO, MC4R and GCK increased the risk of T2D when assessing the Moroccan and Tunisian samples together.
|
22463974 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Common variants near melanocortin receptor 4 (MC4R) have been related to fatness and type 2 diabetes.
|
19844209 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
FTO (OR = 1.71; CI<sub>95 %</sub> = 1.14-2.57; p = 0.008) and APOB (OR = 0.31; CI<sub>95 %</sub> = 0.14-0.72; p = 0.004) result is statistically associated to high blood pressure and FTO (OR = 2.0; CI<sub>95 %</sub> = 1.3-3.1; p = 0.001), GNB3 (OR = 2.69; CI<sub>95 %</sub> = 1.0-7.2; p = 0.04), IFI30 (OR = 2.0; CI<sub>95 %</sub> = 1.16-3.6; p = 0.01), and MC4R (OR = 1.81; CI<sub>95 %</sub> = 1.13-2.9; p = 0.01) to type 2 diabetes (T2D).
|
28035522 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association with type 2 diabetes (P<or=0.05), of whom the three first would stand correction for multiple testing: CDKN2A/B rs10811661, OR: 1.26 (1.12-1.43) P = 1.8*10(-4); CDKAL1 rs10946398, OR: 1.23 (1.09-1.39); P = 7.1*10(-4), and TCF7L2 rs7903146, OR: 1.61 (1.19-2.18) P = 2.3 * 10(-3).
|
20161779 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we evaluated the association of two variants (rs12970134 and rs4450508) near MC4R and a nonsynonymous (Gln241His) variant (rs3812316) in MLXIPL gene with type 2 diabetes (T2D) and obesity-related QTs in our case-control cohort (n = 1,528; 745 T2D cases and 783 controls) from a Sikh population from North India.
|
19680233 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this first study of Arab descendants, we confirmed several known obesity (FTO, USP37, and RFX7), height (NSD1, MFAP2), and T2DM (TCF7L2, MC4R) associations; and report novel associations, like KCNK3 and RARB for T2DM.
|
29717269 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Likewise, its homologous MC4R in human obesity, MC3R gene is also a good candidate for genetic susceptibility to glucose intolerance and T2DM.
|
11397906 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Notable associations observed for genes previously identified at genome-wide significance in other populations included MC4R (Pgenotyped = 4.49x10-4) for BMI and IGF2BP2 Pimputed_1000G = 2.55x10-6) for T2D.
|
25760438 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of the 5 SNPs analyzed, POL1-nearby variant rs488846 [P=0.044], and MC4R-nearby variant rs1942872 [P=0.012] were associated with moderate risk of T2DM.
|
23727064 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prospectively, we demonstrated that each FTO and MC4R risk allele increased obesity and T2D incidences by 24% (P = 0.02) and 21% (P = 0.02), respectively.
|
19255736 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry.
|
23457408 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Since the report of the MC4R knockout mouse in 1997, the field has been searching for links between this genetic biomarker and human obesity and type 2 diabetes.
|
20462274 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Single SNP analysis showed that genetic variants in SLC30A10, TMEM18, GNPDA2, PRL, TFAP2B, BDNF, MTCH2, FTO, and MC4R were nominally associated with waist circumference (WC), BMI, and risk for abdominal or general obesity in the untreated patients with type 2 diabetes, as well as in the total group of patients with type 2 diabetes (untreated and treated) (p < 0.05).
|
31167208 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Six separate groups were identified.Individuals with a more modern birth year, an MC4R mutation, or in utero exposure to T2D were clustered in the two groups with high increasing and chronic overweight z-scores (P < 0.0001).
|
26308479 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood.
|
22106157 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The interaction between MC4R genes with dietary factors plays a significant role in the development of obesity or Type 2 diabetes phenotypes.
|
26666384 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The melanocortin-4 receptor (MC4-R) regulates food intake and possibly energy expenditure, and the inactivation of the MC4-R by gene targeting results in obesity, a phenotype strongly associated with Type II (non-insulin-dependent) diabetes mellitus.
|
11692184 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The objective was to investigate the genetic markers related to obesity genes FTO and MC4R and the gene of type 2 diabetes mellitus TCF7L2 for their contribution to risk of stroke and transient ischemic attacks (TIA).
|
21921652 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is no evidence supporting an association between variants in the fat mass- and obesity-associated and melanocortin 4 receptor, and a member of the potassium voltage-gated channels genes and type 2 diabetes in the Saudi population.
|
25501231 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These novel results suggest that the association of the FTO-rs9939609 and the MC4R-rs17782313 polymorphisms with type 2 diabetes depends on diet and that a high adherence to the MedDiet counteracts the genetic predisposition.
|
23130628 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of FTO rs9939609 and MC4R rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients.
|
23849767 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals.
|
19073769 |
2009 |