Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 AlteredExpression disease BEFREE In addition to its role as an antioxidant enzyme, PRX2 exhibited anti-apoptotic effects in DA neurons via suppression of apoptosis signal-regulating kinase (ASK1)-dependent activation of the c-Jun N-terminal kinase/c-Jun and p38 pro-death pathways, which are also activated in DA neurons of postmortem PD brains. 21209210 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 AlteredExpression disease BEFREE This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. 16515547 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 Biomarker disease BEFREE These findings collectively support inhibiting ASK1 as a disease modifying therapeutic strategy for Parkinson disease and related α-synucleinopathies. 31734439 2020
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 Biomarker disease BEFREE These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD. 28888991 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 AlteredExpression disease LHGDN This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. 16515547 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 Biomarker disease BEFREE In other contexts, both the NFκB (nuclear factor κB) pathway and the ASK1 (apoptosis signaling kinase 1) pathway have been shown to be regulated by both Grx1 and Trx1, and both pathways have been implicated in cell death signaling in model systems of PD. 21815648 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 Biomarker disease CTD_human In other contexts, both the NFκB (nuclear factor κB) pathway and the ASK1 (apoptosis signaling kinase 1) pathway have been shown to be regulated by both Grx1 and Trx1, and both pathways have been implicated in cell death signaling in model systems of PD. 21815648 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 GeneticVariation disease BEFREE Consequently, the peripheral cysteine mutants retained cytoprotective activity, whereas the PD-associated mutant [M26I]DJ-1 failed to suppress ASK1 activity and nuclear export of the death domain-associated protein Daxx and did not promote cytoprotection. 19293155 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.310 GeneticVariation disease BEFREE Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin. 24008424 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.310 Biomarker disease CTD_human The position of the mutations and the loss of heterozygosity of MAP3K5 and MAP3K9 in 85% and 67% of melanoma samples, respectively, together suggest that the mutations are likely to be inactivating. 22197930 2011
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker disease CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.300 Biomarker disease CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Biomarker disease CTD_human Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. 18700144 2008
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker disease CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Biomarker disease CTD_human Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. 18700144 2008
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Biomarker disease CTD_human Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. 18700144 2008
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker disease CTD_human Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. 18700144 2008
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Biomarker disease CTD_human Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. 18700144 2008
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.240 Biomarker disease BEFREE Many experimental studies have shown the association of apoptosis signal-regulating kinase 1 (ASK1) with cellular pathomechanisms after cerebral ischemia. 29743976 2018
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.240 AlteredExpression disease BEFREE Here we reported ASK1 was activated by nitric oxide (NO) through S-nitrosylation during cerebral ischemia-reperfusion. 23137546 2013
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.240 Biomarker disease BEFREE Herein, we focus on apoptosis signal-regulating kinase 1 (ASK1), which is involved in apoptotic cell death, brain infarction, and production of inflammatory mediators after cerebral ischemia. 28855861 2017
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.240 Therapeutic disease RGD As a result of RNAi, corresponding mRNA was distinctly degraded, expression of Ask1 protein was obviously suppressed, apoptotic cell death was apparently decreased and cerebral infarct area was significantly reduced. 23968852 2013
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.240 Biomarker disease BEFREE The objective of the present study was to evaluate the role of ASK1 in controlling NLRP2 inflammasomes in astrocytes after cerebral ischemia. 30172704 2018
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker disease RGD Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion. 23137546 2013
CUI: C0017665
Disease: Membranous glomerulonephritis
Membranous glomerulonephritis 		0.200 Biomarker disease RGD Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury. 18178252 2008