Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 Biomarker disease BEFREE Our results indicate that ASK1 induces apoptosis in neuroblastoma cells mainly via the p38 MAPK pathway, and resistant neuroblastoma cells can be sensitised to ASK1 by paclitaxel. 11598801 2001
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.050 Biomarker disease BEFREE Our results indicate that ASK1 induces apoptosis in neuroblastoma cells mainly via the p38 MAPK pathway, and resistant neuroblastoma cells can be sensitised to ASK1 by paclitaxel. 11598801 2001
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.050 Biomarker disease BEFREE Our results indicate that ASK1 induces apoptosis in neuroblastoma cells mainly via the p38 MAPK pathway, and resistant neuroblastoma cells can be sensitised to ASK1 by paclitaxel. 11598801 2001
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker disease RGD Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. 12786973 2003
CUI: C2936380
Disease: Neointima
Neointima 		0.200 Therapeutic disease RGD Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia. 14638553 2003
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE ASK1 regulates influenza virus infection-induced apoptotic cell death. 12878192 2003
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 PosttranslationalModification disease BEFREE Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. 14500571 2004
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 PosttranslationalModification disease BEFREE Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. 14500571 2004
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.020 PosttranslationalModification disease BEFREE Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. 14500571 2004
CUI: C0016057
Disease: Fibrosarcoma
Fibrosarcoma 		0.010 AlteredExpression disease BEFREE NO has now been shown to inhibit the activation of apoptosis signal-regulating kinase 1 (ASK1) in murine fibrosarcoma L929 cells through such a mechanism. 14668338 2004
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.010 AlteredExpression disease BEFREE NO has now been shown to inhibit the activation of apoptosis signal-regulating kinase 1 (ASK1) in murine fibrosarcoma L929 cells through such a mechanism. 14668338 2004
CUI: C0334463
Disease: Malignant Fibrous Histiocytoma
Malignant Fibrous Histiocytoma 		0.010 Biomarker disease BEFREE ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications. 15034865 2004
CUI: C0003864
Disease: Arthritis
Arthritis 		0.030 Biomarker disease BEFREE The effect of apoptosis signal-regulating kinase 1 gene transfer on rat collagen induced arthritis. 16331767 2005
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 Biomarker disease BEFREE The ASK1DeltaN and Cre adenovirus vectors were cotransduced into cultured synoviocytes derived from patients with rheumatoid arthritis (RA), and apoptosis was evaluated by TUNEL and Hoechst staining. 16331767 2005
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne 		0.010 Biomarker disease BEFREE The transforming growth factor (TGF)-beta pathway was strongly induced in symptomatic patients, with expression of TGFbeta type II receptor and apoptosis signal-regulating kinase 1 proteins on subsets of mature DMD myofibers. 16093456 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 AlteredExpression disease BEFREE This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. 16515547 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 AlteredExpression disease LHGDN This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. 16515547 2006
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.340 Biomarker group CTD_human Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. 16731828 2006
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 AlteredExpression disease BEFREE We observed significant activation of ASK1, p38 and JNK, as well as apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells exposed to 6-OHDA. 16515547 2006
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.050 AlteredExpression disease BEFREE We observed significant activation of ASK1, p38 and JNK, as well as apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells exposed to 6-OHDA. 16515547 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 Biomarker disease BEFREE Here, we examined roles of mitochondrial ROS and ASK1 in TNF-alpha-induced impaired insulin signaling in cultured human hepatoma (Huh7) cells. 16644673 2006
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.050 AlteredExpression disease BEFREE We observed significant activation of ASK1, p38 and JNK, as well as apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells exposed to 6-OHDA. 16515547 2006
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.010 AlteredExpression disease BEFREE Here, we show that high glucose induces activation of apoptosis signal-regulating kinase 1 (ASK1), an apoptosis-inducing signal that mediates endothelial cell senescence induced by hyperglycemia. 16731828 2006
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 Biomarker group BEFREE Here, we examined roles of mitochondrial ROS and ASK1 in TNF-alpha-induced impaired insulin signaling in cultured human hepatoma (Huh7) cells. 16644673 2006
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.010 Biomarker disease LHGDN Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. 16532036 2006