Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker disease CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.300 Biomarker disease CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary 		0.300 Biomarker group CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0036529
Disease: Myocardial Diseases, Secondary
Myocardial Diseases, Secondary 		0.300 Biomarker group CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker disease CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.300 Biomarker group CTD_human 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. 18342293 2008
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.340 AlteredExpression group BEFREE Diabetes was associated with higher OM Ask1-mRNA only in the lean group. 19351724 2009
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 AlteredExpression disease BEFREE Diabetes was associated with higher OM Ask1-mRNA only in the lean group. 19351724 2009
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE ASK1 regulates influenza virus infection-induced apoptotic cell death. 12878192 2003
CUI: C0334463
Disease: Malignant Fibrous Histiocytoma
Malignant Fibrous Histiocytoma 		0.010 Biomarker disease BEFREE ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications. 15034865 2004
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses. 19931259 2010
CUI: C0009319
Disease: Colitis
Colitis 		0.020 Biomarker disease BEFREE ASK1 deficiency increased susceptibility to colonic inflammation in both models of colitis. 19931259 2010
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 Biomarker disease BEFREE Apoptosis signal-regulating kinase 1 is associated with the effect of claudin-6 in breast cancer. 22925655 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 Biomarker disease BEFREE Apoptosis signal-regulating kinase 1 is associated with the effect of claudin-6 in breast cancer. 22925655 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE ASK1, a member of the MAPK Kinase Kinase family of proteins has been shown to play a key role in cancer, neurodegeneration and cardiovascular diseases and is emerging as a possible drug target. 23776076 2013
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE ASK1, a member of the MAPK Kinase Kinase family of proteins has been shown to play a key role in cancer, neurodegeneration and cardiovascular diseases and is emerging as a possible drug target. 23776076 2013
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 Biomarker group BEFREE ASK1, a member of the MAPK Kinase Kinase family of proteins has been shown to play a key role in cancer, neurodegeneration and cardiovascular diseases and is emerging as a possible drug target. 23776076 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Apoptosis signal-regulating kinase 1 (ASK1) is involved in death receptor-mediated apoptosis and may acts as a tumor suppressor in hepatocarcinogenesis. 27050273 2016
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.010 Biomarker disease BEFREE Apoptosis signal-regulating kinase 1 (ASK1) is involved in death receptor-mediated apoptosis and may acts as a tumor suppressor in hepatocarcinogenesis. 27050273 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.010 Biomarker disease BEFREE ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype. 28702328 2017
CUI: C2973725
Disease: Pulmonary arterial hypertension
Pulmonary arterial hypertension 		0.010 Biomarker disease BEFREE ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. 28910144 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 Biomarker group BEFREE ASK1 inhibition reduced pathological remodeling of the pulmonary vasculature and the right ventricle and halted progression of pulmonary hypertension in rodent models. 28910144 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE ASK1 is known to be important for macrophage activation and inflammation-mediated tumorigenesis. 28931753 2017
CUI: C2242703
Disease: Cardio-Renal Syndrome
Cardio-Renal Syndrome 		0.010 Biomarker disease BEFREE ASK1 inhibitor is an effective therapeutic agent to alleviate protein-bound uremic toxin-induced cardiac hypertrophy and cardiorenal fibrosis in vitro, and may be translated further for cardiorenal syndrome therapy. 29107962 2017
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 Biomarker disease BEFREE Apoptosis Signal-Regulating Kinase 1 (ASK1) Activation is Involved in Silver Nanoparticles Induced Apoptosis of A549 Lung Cancer Cell Line. 29381295 2017