|
Severe Dengue
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations.
|
28599625 |
2017 |
|
Severe Dengue
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of MICB and PLCE1 and associations with non-severe dengue.
|
23536857 |
2013 |
|
Severe Dengue
|
0.430 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
|
22001756 |
2011 |
|
Severe Dengue
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
|
22001756 |
2011 |
|
Severe Dengue
|
0.430 |
Biomarker
|
disease |
BEFREE |
A sequencing-based typing method and genotyping of MICA and MICB in a well-characterized group of Cuban individuals with dengue hemorrhagic fever (DHF), dengue fever (DF), or asymptomatic dengue infection (ADI) was performed.
|
21762746 |
2011 |
|
Dengue Shock Syndrome
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at MICB rs3132468 and PLCE1 rs3740360.
|
23536857 |
2013 |
|
Dengue Shock Syndrome
|
0.410 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
|
22001756 |
2011 |
|
Dengue Shock Syndrome
|
0.410 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
|
22001756 |
2011 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
BEFREE |
These included microtubule-related MAP2 and MAPT, as well as WNT3 and MICB, all implicated in the pathogenesis of diseases such as Parkinson's, Alzheimer's and schizophrenia.
|
31504236 |
2019 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk.
|
17561376 |
2007 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk.
|
17561376 |
2007 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk.
|
17561376 |
2007 |
|
Rheumatoid Arthritis
|
0.130 |
Biomarker
|
disease |
BEFREE |
Our results indicated that MICB*002 and MICB*014 were less frequent in RA patients than in controls (P = 0.000, 0.005) while there were higher percentages of RA patients carrying MICA*009 and MICA*A6 (P = 0.005).
|
29665245 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggested that the MICB*009N allele might be a risk factor for SLE, whereas the MICB*014, MICA*010 and MICB*002 alleles were associated with reduced incidence of SLE in the study population.
|
29078849 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE.
|
27433477 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Our results from conditional analysis and model choice with the use of the Bayesian information criterion show that the best model for SLE association includes both classical loci (HLA-DRB1(∗)03:01, HLA-DRB1(∗)08:01, and HLA-DQA1(∗)01:02) and two SNPs, rs8192591 (in class III and upstream of NOTCH4) and rs2246618 (MICB in class I).
|
23084292 |
2012 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
We previously revealed that one of the human leukocyte antigen-linked susceptibility genes for Takayasu's arteritis (TA) was mapped between TNFA and MICB loci and that -63T allele of NFKBIL1, which is between TNFA and MICB loci, was associated with rheumatoid arthritis (RA) in the Japanese population.
|
16720219 |
2006 |
|
Rheumatoid Arthritis
|
0.130 |
Biomarker
|
disease |
BEFREE |
In this critical segment, four expressed genes have been thus far identified, NFKBIL1 (IkappaBL), ATP6G, BAT1, and MICB, all of which are candidate genes for determining susceptibility to RA.
|
11170743 |
2001 |
|
Behcet Syndrome
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.
|
23001997 |
2012 |
|
Behcet Syndrome
|
0.120 |
Biomarker
|
disease |
BEFREE |
Our results suggest that while MICB does not influence the development of BD, polymorphisms in MICA may be pathogenic, perhaps through the interaction with NK and gammadelta T cells.
|
16101830 |
2005 |
|
Behcet Syndrome
|
0.120 |
Biomarker
|
disease |
BEFREE |
This result suggests that the MICB gene itself is not responsible for the development of BD, and that the candidate gene(s) for BD is located between the MICA and HLA-C genes.
|
9712354 |
1998 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |