DisGeNET - a database of gene-disease associations

MICB, MHC class I polypeptide-related sequence B, 4277

N. diseases: 95; N. variants: 19

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs3132468

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0019100
Disease:

Severe Dengue

0.710

GeneticVariation

BEFREE

A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations.

28599625

2017

dbSNP:

rs3132468

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0376300
Disease:

Dengue Shock Syndrome

0.710

GeneticVariation

BEFREE

A recent genome-wide association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at MICB rs3132468 and PLCE1 rs3740360.

23536857

2013

dbSNP:

rs3132468

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0376300
Disease:

Dengue Shock Syndrome

0.710

GeneticVariation

GWASDB

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

22001756

2011

dbSNP:

rs3132468

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0019100
Disease:

Severe Dengue

0.710

GeneticVariation

GWASCAT

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

22001756

2011

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C1269683
Disease:

Major Depressive Disorder

0.700

GeneticVariation

GWASCAT

Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

31619474

2019

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0264408
Disease:

Childhood asthma

0.700

GeneticVariation

GWASCAT

Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

31619474

2019

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0004096
Disease:

Asthma

0.700

GeneticVariation

GWASCAT

Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.

31619474

2019

dbSNP:

rs9378160

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0236664
Disease:

Alcohol-Related Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs9378160

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs9378160

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0236970
Disease:

Alcohol-Induced Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs2534681

Entrez Id:	4277;102725068
Gene Symbol:	MICB;MICB-DT

MICB;MICB-DT

CUI:	C0596887
Disease:

mathematical ability

0.700

GeneticVariation

GWASCAT

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

30038396

2018

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0004096
Disease:

Asthma

0.700

GeneticVariation

GWASCAT

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

29273806

2018

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C2985280
Disease:

Blood Protein Measurement

0.700

GeneticVariation

GWASCAT

Co-regulatory networks of human serum proteins link genetics to disease.

30072576

2018

dbSNP:

rs3134900

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C2985280
Disease:

Blood Protein Measurement

0.700

GeneticVariation

GWASCAT

Genomic atlas of the human plasma proteome.

29875488

2018

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C1266708
Disease:

Polybrominated biphenyl measurement

0.700

GeneticVariation

GWASCAT

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants.

28235828

2017

dbSNP:

rs2507971

Entrez Id:	4277;102725068
Gene Symbol:	MICB;MICB-DT

MICB;MICB-DT

CUI:	C0200637
Disease:

Monocyte count procedure

0.700

GeneticVariation

GWASCAT

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

27863252

2016

dbSNP:

rs2507971

Entrez Id:	4277;102725068
Gene Symbol:	MICB;MICB-DT

MICB;MICB-DT

CUI:	C0750880
Disease:

Monocyte count result

0.700

GeneticVariation

GWASCAT

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

27863252

2016

dbSNP:

rs3130614

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0027121
Disease:

Myositis

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

26291516

2015

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0024141
Disease:

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASDB

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

24871463

2014

dbSNP:

rs2534657

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0019829
Disease:

Hodgkin Disease

0.700

GeneticVariation

GWASDB

Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.

24149102

2013

dbSNP:

rs2246618

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0030809
Disease:

Pemphigus Vulgaris

0.700

GeneticVariation

GWASDB

Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris.

22437316

2012

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0026896
Disease:

Myasthenia Gravis

0.700

GeneticVariation

GWASDB

Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.

23055271

2012

dbSNP:

rs3093953

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0004943
Disease:

Behcet Syndrome

0.700

GeneticVariation

GWASDB

Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

23001997

2012

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C3160731
Disease:

Pulmonary function (finding)

0.700

GeneticVariation

GWASDB

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

21946350

2011

dbSNP:

rs2855812

Entrez Id:	4277
Gene Symbol:	MICB

MICB

CUI:	C0231921
Disease:

Pulmonary function

0.700

GeneticVariation

GWASDB

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

21946350

2011