|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
CTD_human |
Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice.
|
20127836 |
2010 |
|
Inflammation
|
0.560 |
GeneticVariation
|
phenotype |
LHGDN |
Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis.
|
18097599 |
2008 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
LHGDN |
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
|
18235500 |
2008 |
|
Inflammation
|
0.560 |
GeneticVariation
|
phenotype |
LHGDN |
Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis.
|
17786285 |
2007 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
RGD |
The results indicate that macrophage migration inhibitory factor plays a crucial role in airway inflammation and airway hyperresponsiveness in asthma.
|
16455830 |
2006 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
LHGDN |
Role of macrophage migration inhibitory factor (MIF) in the skin.
|
15659324 |
2005 |
|
Inflammation
|
0.560 |
AlteredExpression
|
phenotype |
LHGDN |
Helicobacter pylori infection is associated with increased expression of macrophage migratory inhibitory factor--by epithelial cells, T cells, and macrophages--in gastric mucosa.
|
15216464 |
2004 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
LHGDN |
The late morning peak of macrophage migration inhibitory factor, by antagonizing cortisol-mediated pro-inflammatory cytokine suppression may prolong the duration of early morning inflammation.
|
12631237 |
2003 |
|
Colitis
|
0.510 |
Biomarker
|
disease |
RGD |
Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat.
|
17324399 |
2007 |
|
Colitis
|
0.510 |
Therapeutic
|
disease |
CTD_human |
Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice.
|
12105854 |
2002 |
|
Colitis
|
0.510 |
Biomarker
|
disease |
BEFREE |
Thus, murine colitis is dependent on continuous MIF production by the innate immune system.
|
11668338 |
2001 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the association of MIF promoter polymorphisms (-794CATT<sub>5-8</sub> rs5844572 and -173G > C, rs755622), circulating MIF levels, and mRNA expression with RA susceptibility and disease activity.
|
31701681 |
2020 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
At T0, the patients with RA had significantly lower levels of MIF and significantly higher levels of interleukin (IL)-18 and MIC-1 compared with controls.
|
31381601 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, genetic variants of the MIF promoter modulate the secretion of cytokines related to the Th17 profile in PBMC from CS inducing a differential response in comparison to PBMC from RA patients.
|
30467094 |
2019 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms in the upstream region exist in the MIF gene and are associated with RA susceptibility or severity in different populations.
|
23402792 |
2013 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The cytokine macrophage migration inhibitory factor (MIF) has been shown to affect bone density in rodents, and polymorphisms in the human MIF promoter are associated with inflammatory disorders such as rheumatoid arthritis.
|
20471506 |
2010 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between macrophage migration inhibitory factor-173 gene polymorphism with disease susceptibility and cardiovascular risk in rheumatoid arthritis patients from northwestern Spain.
|
20346241 |
2010 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Induction of macrophage migration inhibitory factor in ConA-stimulated rheumatoid arthritis synovial fibroblasts through the P38 map kinase-dependent signaling pathway.
|
20830230 |
2010 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility.
|
17869648 |
2007 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MIF gene has been associated with several diseases with inflammatory and autoimmune background, such as ulcerative colitis, rheumatoid arthritis and systemic lupus erythematosus.
|
17215861 |
2007 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis.
|
17456524 |
2007 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the -173C allele in the MIF promoter region is associated with increased RA predisposition, mainly in early-onset patients.
|
17869648 |
2007 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis.
|
16872482 |
2006 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis.
|
16872482 |
2006 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We therefore investigated if the -G173C single nucleotide polymorphism (SNP) and the tetranucleotide repeat CATT (5 - 8) at position -794 of the MIF gene and the CD14 - C159T transition are candidates for genetic liability to schizophrenia and RA or could explain the negative association between them.
|
16916546 |
2006 |