|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The SBF2-AS1-miR-338-3p/362-3p-E2F1 regulatory axis may serve as a prognostic marker and potential therapeutic target for LUAD.
|
31071530 |
2019 |
|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the role of microRNA-205 and microRNA-338-3p and cell apoptosis in prostate carcinoma tissue and the LNCaP human prostate adenocarcinoma cell line by directly targeting the BCL2 gene and Bcl-2 protein expression.
|
30741252 |
2019 |
|
Adenoid Cystic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p.
|
30672444 |
2018 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Further, low miR-338-3p expression is associated with increased mortality and disease progression in patients with glioblastoma.
|
28493990 |
2017 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
MiR-338-5p sensitizes glioblastoma cells to radiation through regulation of genes involved in DNA damage response.
|
26692101 |
2016 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results confirm that miR-338, a tumor suppressor, suppresses the PKM2/β-catenin axis and is downregulated in glioblastoma.
|
28858851 |
2017 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the expression of miR-338-5p, normalized to hsnRNA U6, was significantly higher in grade III and IV gliomas and glioblastoma cell lines compared to that in NNB and grade II gliomas, whereas TSHZ3 expression, normalized to GAPDH, was inversely related to miR-338-5p (R = -0.636, P < 0.01).
|
28780604 |
2018 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To determine whether and how miR-338-3p influences liver cancer cell invasion, we studied miR-338-3p in the liver cancer cell lines, and we found that miR-338-3p is down-regulated in treated cells.
|
21671467 |
2011 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings indicate that miR-338-3p influences the development of LC by targeting SphK2, suggesting that miR-338-3p can be targeted as an innovative therapeutic strategy for LC.
|
29321083 |
2018 |
|
Adult Lymphoblastic Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR‑338‑3p suppresses the malignancy of T‑cell lymphoblastic lymphoma by downregulating HOXA3.
|
31322185 |
2019 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that down-regulated expression of miR-338-5p plays an important role in the development of AD.-Qian, Q., Zhang, J., He, F.-P., Bao, W.-X., Zheng, T.-T., Zhou, D.-M., Pan, H.-Y., Zhang, H., Zhang, X.-Q., He, X., Sun, B.-G., Luo, B.-Y., Chen, C., Peng, G.-P. Down-regulated expression of microRNA-338-5p contributes to neuropathology in Alzheimer's disease.
|
30576233 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
One of these miRNAs, miR-338-3p, has previously been shown to be de-regulated in ALS brains.
|
22903028 |
2012 |
|
Amyotrophic Lateral Sclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
This approach revealed elevated levels of 5 miRNAs and reduced levels of 22 miRNAs in EVs collected from PALS as compared with healthy controls subjects. miRNAs with relevance to ALS were found to be deregulated, including miR-9-5p, miR-183-5p, miR-338-3p and miR-1246.
|
30552897 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate the differential expression of 10 miRNAs, including miR-9, miR-338, miR-638, miR-663a, miR-124a, miR-143, miR-451a, miR-132, miR-206, and let-7b, for which some connection to ALS was shown previously in ALS culture cells, animal models or patients, and in three miRNA host genes, including <i>C1orf61</i> (miR-9), <i>AATK</i> (miR-338), and <i>DNM2</i> (miR-638), in leukocyte samples of 84 patients with sporadic ALS.
|
29670510 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
By microarray analysis, we identified up-regulation of miR-29a, miR-29b and miR-338-3p in amyotrophic lateral sclerosis brains, but due to a great interindividual variation, we could not validate these results by quantitative RT-PCR.
|
20202123 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Decreased Glycogenolysis by <i>miR-338-3p</i> Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice.
|
31133799 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
This study presents the direct experimental evidence that, overall, miR-338-3p is highly expressed in ALS tissues including neuromuscular junction characterizing ALS from normal tissues.
|
30154826 |
2018 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety.
|
28184278 |
2017 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety.
|
28184278 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study thus suggests that miR-338-3p promoted ox-LDL-induced HUVEC cell injury by targeting BAMBI and activating the TGF-β/Smad pathway, which may provide a novel and promising therapeutic target for AS.
|
30556591 |
2019 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study thus suggests that miR-338-3p promoted ox-LDL-induced HUVEC cell injury by targeting BAMBI and activating the TGF-β/Smad pathway, which may provide a novel and promising therapeutic target for AS.
|
30556591 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene.
|
30741252 |
2019 |
|
Benign Ovarian Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results</b> The expressions of miR-338-3p and MACC1 gene in epithelial ovarian cancer tissues were (0.331±0.038) and (0.774±0.025), significant differences were noted between epithelial ovarian cancer and normal ovarian tissues, benign ovarian tumors (F=77.916, <i>P</i>=1.205E-18; F=77.945, <i>P</i>=1.187E-18).
|
31031848 |
2019 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
miR-338-3p and ETS1 expressions were examined by quantitative Real-time polymerase chain reaction (qRT-PCR) in BC samples.
|
30915741 |
2019 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In our study, miR-338-3p and miR-338-5p were differentially expressed in GBM tissue in comparison to non-tumor brain tissue.
|
26692101 |
2016 |