Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pooled results presented that MTHFR C677T polymorphism was significantly associated with T2DM under homozygous (OR = 1.64, 95% CI = 1.39-1.94), heterozygous (OR = 1.38, 95% CI = 1.20-1.59), recessive (OR = 1.41, 95% CI = 1.23-1.61), dominant (OR = 1.47, 95% CI = 1.27-1.70), and allele (OR = 1.37, 95% CI = 1.23-1.52) genetic models.
|
31663297 |
2019 |
Depressive Symptoms
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Third, higher age 7 MTHFR DNAm associated with higher initial symptoms of depression symptoms at age 8, again at a small effect size.
|
31621343 |
2019 |
Depression in children
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Serum cholesterol, MTHFR methylation, and symptoms of depression in children.
|
31621343 |
2019 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MTHFR polymorphisms could be used as a diagnostic marker for autism with respect to ethnicity background.
|
31614268 |
2019 |
Behcet Syndrome
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
|
31602349 |
2019 |
Acute Coronary Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of recurrent thrombotic acute coronary syndrome (ACS) in a patient with diabetes, compound heterozygous MTHFR mutations, Behcet's disease with normal C-reactive protein (CRP), and no evidence of diffuse coronary artery disease.
|
31602349 |
2019 |
Hyalinosis, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found 4 positive sites for HFS in the TYMS and MTHFR genes: TYMS rs2606241 (P = 0.022), TYMS rs2853741 (P = 0.019), MTHFR rs3737964 (P = 0.029), and MTHFR rs4846048 (P = 0.030).
|
31601265 |
2019 |
Deep Vein Thrombosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations in apparently healthy individuals residing in Mumbai and patients with deep vein thrombosis (DVT) and coronary artery disease (CAD) and to correlate these polymorphisms with homocysteine (Hcy) levels.
|
31571711 |
2020 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations in apparently healthy individuals residing in Mumbai and patients with deep vein thrombosis (DVT) and coronary artery disease (CAD) and to correlate these polymorphisms with homocysteine (Hcy) levels.
|
31571711 |
2020 |
Hemophilic arthropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The distribution of risk genotypes for MTHFR and TNFα-308GA suggests their association with clinical parameters of hemophilic arthropathy.
|
31566926 |
2019 |
cervical cancer
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis.
|
31554347 |
2019 |
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study has not shown a significant association between MTHFR gene polymorphisms and breast cancer risk.
|
31523170 |
2019 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study has not shown a significant association between MTHFR gene polymorphisms and breast cancer risk.
|
31523170 |
2019 |
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our investigation revealed that the 5,10-MTHFR 677 C/T and 5,10-MTHFR 677T/T genotypes are associated with susceptibility to pediatric ALL (OR = 1.9, 95% IC = 1.36-12.09, p = 0.012 and OR = 2.8, 95% CI = 1.49-22.82, p = 0.011, respectively).
|
31499477 |
2019 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
|
31499477 |
2019 |
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
|
31499477 |
2019 |
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Screening for MTHFR polymorphisms in addition to homocysteine levels may be considered for patients presenting with premature CAD and a normal lipid profile.
|
31497444 |
2019 |
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our case demonstrates the association of MTHFR polymorphism with premature CAD and myocardial infarction (MI) despite normal homocysteine levels.
|
31497444 |
2019 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the MTHFR 677C>T Polymorphism with Obesity and Biochemical Variables in a Young Population of Mexico.
|
31496910 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aim to verify the correlation between MTHFR polymorphisms and clinical features of schizophrenia, while exploring the differential genomic methylation and disease related genes as the potential targets for schizophrenia.
|
31476590 |
2019 |
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis on associations of FTO, MTHFR and TCF7L2 polymorphisms with polycystic ovary syndrome.
|
31470081 |
2020 |
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For MTHFR C677T and A1298C, significant association with PCOS was observed in the combined population and Asian population.
|
31454542 |
2019 |
Eclampsia
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant differences were observed in genotype or allele frequencies between the pre-eclampsia and normal control for the C677T polymorphism of MTHFR gene (<i>p</i> > .05).
|
31452430 |
2019 |