|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variations of the 5, 10- methylenetetrahydrofolate reductase (MTHFR) gene -the main genetic determinant of hyperhomocystenemia in humans-as well the interferon regulatory factor-8 (IRF8), FcγRIIA and BAFF genes have been all linked to subclinical atherosclerosis in SLE.
|
31444033 |
2019 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variations of the 5, 10- methylenetetrahydrofolate reductase (MTHFR) gene -the main genetic determinant of hyperhomocystenemia in humans-as well the interferon regulatory factor-8 (IRF8), FcγRIIA and BAFF genes have been all linked to subclinical atherosclerosis in SLE.
|
31444033 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Variations of the 5, 10- methylenetetrahydrofolate reductase (MTHFR) gene -the main genetic determinant of hyperhomocystenemia in humans-as well the interferon regulatory factor-8 (IRF8), FcγRIIA and BAFF genes have been all linked to subclinical atherosclerosis in SLE.
|
31444033 |
2019 |
|
Cardiac Arrest
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation' and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population.
|
31440871 |
2019 |
|
Vaso-Occlusive Crisis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation' and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population.
|
31440871 |
2019 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association Between MTHFR Genetic Polymorphism and Parkinson's Disease Susceptibility: A Meta-analysis.
|
31428686 |
2019 |
|
Retinal Vein Occlusion
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Background</b>: To study the association of the most common methylenetetrahydrofolate reductase (<i>MTHFR</i>) genetic polymorphisms C677T and A1298C with retinal vein occlusion (RVO) in a Spanish population.
|
31418317 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate Reductase Gene C677T and A1298C Polymorphic Sequence Variations Influences the Susceptibility to Chronic Myeloid Leukemia in Kashmiri Population.
|
31396477 |
2019 |
|
Thrombophilia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of MTHFR (677C > T and 1298A > C), PAI1 (-675 5G/4G and -844A > G), and F2 (20210G > A), and the F5 Leiden mutation, as well as biochemical parameters for hypercoagulability, were analysed.
|
31389788 |
2019 |
|
Hyperhomocysteinemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of MTHFR were observed in 75% and 56% and the PAI1 -675 5G/4G polymorphism in 100% and 83% of patients with and without HHCE, respectively.
|
31389788 |
2019 |
|
Gestational Diabetes
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
In specific mouse models and embryo culture systems, we assessed the effects of combining maternal diabetes with mutations in genes involved in folate transport and metabolism (methylenetetrahydrofolate reductase [Mthfr] and folic acid receptor 1 [Folr1]).
|
31361376 |
2019 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MTHFR and ABCC2 polymorphisms showed an association with either epilepsy types in general or subtypes and treatment response among Jordanian population.
|
31354331 |
2019 |
|
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Databases, including Medline, EMBASE, Cochrane and Chinese databases (including CNKI, Wanfang and VIP), were searched to identify the relevant articles describing MTHFR polymorphisms in patients with CRC.
|
31330573 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: A meta-analysis.
|
31330573 |
2019 |
|
Miscarriage
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association between of MTHFR C677T, A1298C, F2G20210A, and F5 G1691A genetic variants among Iranian women with recurrent miscarriage.
|
31317253 |
2019 |
|
Cleft upper lip
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Association between methylenetetrahydrofolate reductase polymorphisms and non-syndromic cleft lip with or without palate susceptibility: an updated systematic review and meta-analysis.
|
31303355 |
2019 |
|
Cleft Lip with or without Cleft Palate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms are thought to be involved in the development of cleft lip with or without cleft palate (NSCL/P), but published results are contradictory.
|
31303355 |
2019 |
|
Cleft lip or lips
|
0.050 |
GeneticVariation
|
phenotype |
BEFREE |
Association between methylenetetrahydrofolate reductase polymorphisms and non-syndromic cleft lip with or without palate susceptibility: an updated systematic review and meta-analysis.
|
31303355 |
2019 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The three major MTHFR genotypes (G1793A, C677T, and A1298C) were examined in all subjects and the association between MTHFR polymorphism and clinical features of schizophrenia was analyzed.
|
31302825 |
2019 |
|
Schizophrenia, Childhood
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Inconsistent with expectations, no significant associations were found between MTHFR C677T polymorphism and schizophrenia in children.
|
31302825 |
2019 |
|
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thrombophilic profile (factor V G1691A (Leiden), factor V H1299R (R2), prothrombin G20210A, MTHFR C677T, MTHFR A1298C, factor XIII V34L, β-fibrinogen-455 G-A and plasminogen activator inhibitor (PAI)-1 4G/5G) was evaluated using the cardiovascular diseases (CVD) StripAssay based on DNA isolation, PCR and reverse hybridisation.
|
31300468 |
2019 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The correlation between methylenetetrahydrofolate reductase (<i>MTHFR</i>) polymorphisms and hepatocellular carcinoma (HCC) remains controversial.
|
31282757 |
2019 |
|
Caffeine related disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Some common genes that are included in nutrition-based multigene test panels include CYP1A2 (rate of caffeine break down), MTHFR (folate usage), NOS3 (risk of elevated triglyceride levels related to omega-3 fat intake), and ACE (blood pressure response in related to sodium intake).
|
31254340 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma.
|
31242814 |
2019 |
|
Renal Cell Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma.
|
31242814 |
2019 |