MUC7, mucin 7, secreted, 4589

N. diseases: 35; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.430 Biomarker disease HPO
CUI: C0004096
Disease: Asthma
Asthma 		0.430 Biomarker disease CTD_human
CUI: C0035460
Disease: Rhinitis, Vasomotor
Rhinitis, Vasomotor 		0.010 AlteredExpression disease BEFREE MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC7 were expressed in both the normal and VMR turbinates. 9292181 1997
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.010 AlteredExpression disease BEFREE No remarkable differences were observed in the expression patterns of MUC5B or MUC7 between CF (n = 7) and non-CF (n = 10) bronchial samples. 9651178 1998
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.040 AlteredExpression disease BEFREE Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma. 9865718 1998
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.010 AlteredExpression phenotype BEFREE These results suggest a differential MUC7 gene expression with the onset of malignant transformation of the bladder urothelium. 9865718 1998
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE To provide information regarding the expression of these genes in squamous metaplasia and squamous cell carcinoma, we analyzed and compared the expression of MUC1-MUC7 genes by in situ hybridization in control respiratory mucosa and lesions associated with neoplasia (hyperplasia, metaplasia and dysplasia) and squamous cell carcinomas. 10738241 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 AlteredExpression disease BEFREE To provide information regarding the expression of these genes in squamous metaplasia and squamous cell carcinoma, we analyzed and compared the expression of MUC1-MUC7 genes by in situ hybridization in control respiratory mucosa and lesions associated with neoplasia (hyperplasia, metaplasia and dysplasia) and squamous cell carcinomas. 10738241 2000
CUI: C0004096
Disease: Asthma
Asthma 		0.430 GeneticVariation disease BEFREE The MUC7*5 allele was rarer in the atopic asthmatics than in the atopic non-asthmatics (P = 0.014, OR for no asthma in atopic individuals 3.13, CI 1.01-6.10), and the difference in frequency between all asthmatics and all non-asthmatics was statistically significant (P = 0.009) while there was no difference between atopy and non-atopy (P = 0.199). 11378823 2001
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.040 Biomarker disease BEFREE The overall sensitivity of the MUC7 test for all bladder tumor cases was 66%. 12478110 2003
CUI: C1827293
Disease: Carcinoma of urinary bladder, invasive
Carcinoma of urinary bladder, invasive 		0.010 Biomarker disease BEFREE In contrast to CK-20, analysis of MUC7 demonstrated a high sensitivity and high specificity for carcinoma in situ and invasive bladder cancer, thus fulfilling the criteria of a urinary tumor marker. 12478110 2003
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.040 Biomarker disease BEFREE Our results indicate that MUC7 is a potential marker for bladder cancer. 12837463 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE Cells from the urine of 65 patients with bladder cancer, 15 patients with a negative bladder biopsy for bladder cancer, and 30 healthy volunteers were compared for the following parameters: tumor stage, grade, size, and number, urinary cytology, and expression of MUC7. 12837463 2003
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.040 Biomarker disease BEFREE Our results indicate that MUC7 is a potential marker for bladder cancer. 12837463 2003
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.030 Biomarker disease BEFREE Our results indicate that MUC7 is a potential marker for bladder cancer. 12837463 2003
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell 		0.010 AlteredExpression disease BEFREE To determine whether mucin (MUC) 7 gene expression can be used as a bladder tumor marker for transitional cell carcinoma in patients with bladder carcinoma. 12837463 2003
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.040 Biomarker disease BEFREE These results suggest that MUC7 is a highly specific marker for bladder cancer and may be a useful method for the molecular staging and management of bladder cancer. 14678183 2004
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.040 Biomarker disease BEFREE These results suggest that MUC7 is a highly specific marker for bladder cancer and may be a useful method for the molecular staging and management of bladder cancer. 14678183 2004
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.030 Biomarker disease BEFREE These results suggest that MUC7 is a highly specific marker for bladder cancer and may be a useful method for the molecular staging and management of bladder cancer. 14678183 2004
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection 		0.010 AlteredExpression group BEFREE Nested reverse transcription-polymerase chain reaction (RT-PCR) was performed on four types of bladder cancer cell lines (RT4, T24, EJ-1 and TCC) and the peripheral blood of 38 (31 superficial disease and seven invasive disease) bladder cancer patients and 18 subjects with urinary tract infections or other non-malignant conditions to determine the expression of MUC7. 14678183 2004
CUI: C0262655
Disease: Recurrent urinary tract infection
Recurrent urinary tract infection 		0.010 AlteredExpression disease BEFREE Nested reverse transcription-polymerase chain reaction (RT-PCR) was performed on four types of bladder cancer cell lines (RT4, T24, EJ-1 and TCC) and the peripheral blood of 38 (31 superficial disease and seven invasive disease) bladder cancer patients and 18 subjects with urinary tract infections or other non-malignant conditions to determine the expression of MUC7. 14678183 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.430 GeneticVariation disease BEFREE There was low haplotype diversity and strong association between each of the loci, and the MUC7*5 allele-carrying haplotype remained the one most strongly associated with asthma. 16759176 2006
CUI: C0043144
Disease: Wheezing
Wheezing 		0.010 GeneticVariation phenotype BEFREE We show that the haplotype carrying MUC7*5 is associated with higher FEV1 at 53 years, reduced age-related decline of FEV1, and also reduced incidence of wheeze. 16759176 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 GeneticVariation group BEFREE One gene is a tumour suppressor gene (HLF); two genes act as oncogenes (FGFR3 and LMO3); two genes are involved in matrix degradation (MMP12 and PTHLH); three genes are related to cell differentiation (SPRR1B, RTN1, and MUC7); and five genes have not been well characterized to date. 16915569 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.040 AlteredExpression disease BEFREE The value of combined use of survivin, cytokeratin 20 and mucin 7 mRNA for bladder cancer detection in voided urine. 18026991 2008