Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function mutation in the zinc finger homeobox 3 gene (ZFHX3) is associated with increased risk of AF.
|
31152485 |
2019 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis.
|
31169720 |
2019 |
Atrial Fibrillation
|
0.500 |
Biomarker
|
disease |
CTD_human |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation.
|
30180182 |
2018 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.
|
29290336 |
2018 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
Atrial Fibrillation
|
0.500 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
28416818 |
2017 |
Atrial Fibrillation
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study suggests a contribution of ZFHX3 to AF remodeling and response to therapy.
|
28381281 |
2017 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
|
28460022 |
2017 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes.
|
28007413 |
2017 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) have identified common variants in nine genomic regions associated with AF (KCNN3, PRRX1, PITX2, WNT8A, CAV1, C9orf3, SYNE2, HCN4 and ZFHX3 genes); however, the genetic variability of these risk variants does not explain the entire genetic susceptibility to AF.
|
25391453 |
2015 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients.
|
26272656 |
2015 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
|
26267381 |
2015 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF).
|
25684755 |
2015 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In overall population, the occurrence of AF was found to be associated with T-allelic of rs7193343 SNP in ZFHX3 (OR =1.17, 95% CI 1.10-1.26).
|
26112950 |
2015 |
Atrial Fibrillation
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study, we selected and sequenced 77 target gene regions from GWAS loci of complex diseases or traits, including 4 genes hypothesized to be related to AF (PRRX1, CAV1, CAV2, and ZFHX3).
|
24239840 |
2014 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore the associations between single nucleotide polymorphisms (SNPs) of ZFHX3 and the risk of AF in a Chinese Han population.
|
24983873 |
2014 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Participants were genotyped for common AF susceptibility alleles at chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), and common SNPs in the β1-adrenergic receptor (ARDB1).
|
24910551 |
2014 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The 3 loci most strongly associated with AF occur at chromosome 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3).
|
23428961 |
2013 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
Atrial Fibrillation
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the ZFHX3 gene, encoding a cardiac transcription factor, was associated with increased AF risk in HF patients, and the genetic association with AF was more pronounced in HF patients than in the general population.
|
23132824 |
2013 |