|
ATRIAL FIBRILLATION, FAMILIAL, 18
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
|
27066836 |
2016 |
|
ATRIAL FIBRILLATION, FAMILIAL, 18
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Hypertrophic Cardiomyopathy
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Higher MYL4 expression was also modestly associated with hypertrophic cardiomyopathy (p = 6.3e-04).
|
31481666 |
2019 |
|
Hypertrophic Cardiomyopathy
|
0.340 |
Biomarker
|
disease |
BEFREE |
Most patients with hypertrophic cardiomyopathy and congenital heart diseases express the atrial essential myosin light chains (ALC-1) in their ventricles, replacing the ventricular essential light chains (VLC-1).
|
16106982 |
2005 |
|
Hypertrophic Cardiomyopathy
|
0.340 |
Biomarker
|
disease |
BEFREE |
ToF patients expressed around four times more ALC-1 mRNA for similar amounts of ALC-1 than HOCM patients.
|
10440925 |
1999 |
|
Hypertrophic Cardiomyopathy
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Similarly, we investigated the expression of ALC-1 by two-dimensional polyacrylamide gel electrophoresis and the clinical and hemodynamic parameters of the patients with hypertrophic cardiomyopathy.
|
10569205 |
1999 |
|
Hypertrophic Cardiomyopathy
|
0.340 |
Biomarker
|
disease |
CTD_human |
An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy.
|
9527842 |
1998 |
|
Hypertrophic obstructive cardiomyopathy
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Higher MYL4 expression was also modestly associated with hypertrophic cardiomyopathy (p = 6.3e-04).
|
31481666 |
2019 |
|
Hypertrophic obstructive cardiomyopathy
|
0.330 |
Biomarker
|
disease |
BEFREE |
Most patients with hypertrophic cardiomyopathy and congenital heart diseases express the atrial essential myosin light chains (ALC-1) in their ventricles, replacing the ventricular essential light chains (VLC-1).
|
16106982 |
2005 |
|
Hypertrophic obstructive cardiomyopathy
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Similarly, we investigated the expression of ALC-1 by two-dimensional polyacrylamide gel electrophoresis and the clinical and hemodynamic parameters of the patients with hypertrophic cardiomyopathy.
|
10569205 |
1999 |
|
Hypertrophic obstructive cardiomyopathy
|
0.330 |
Biomarker
|
disease |
CTD_human |
An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy.
|
9527842 |
1998 |
|
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
|
27066836 |
2016 |
|
familial atrial fibrillation
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
|
27066836 |
2016 |
|
Palpitations
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Palpitations, CTCAE
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation.
|
31735076 |
2020 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease.
|
31406021 |
2019 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We discovered a rare frameshift deletion in the myosin MYL4 gene (c.234delC) that associates with early-onset AF under a recessive mode of inheritance (allelic frequency = 0.58%).
|
27742809 |
2017 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In zebrafish, mutant MYL4 leads to disruption of sarcomeric structure, atrial enlargement and electrical abnormalities associated with human AF.
|
27066836 |
2016 |
|
Atrial cardiomyopathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
This screen identified connexin 43 hemichannel (HC) blockade, as a robust suppressor of the abnormal phenotypes in both models of MYL4-related atrial cardiomyopathy.
|
31735076 |
2020 |
|
Atrial cardiomyopathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
We used genetically modified rat models to investigate the role of <i>MYL4</i> in atrial cardiomyopathy.
|
29080865 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that the transcriptional level of ALC1 was not upregulated in breast cancer tissues.CHFR interacted with ALC1.
|
31322269 |
2019 |
|
Heart Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease.
|
31406021 |
2019 |
|
Lymphopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The 102 patients with ALC1 ≤1,479 cells/μl (defined as lymphopenia) had significantly higher 10-year IBTR rate than the 102 patients with ALC1 >1,479 cells/μl (16.2% vs. 1%, p=0.0034).
|
31366546 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ALC1 is a new oncogene involved in the invasion and metastasis of breast cancer.
|
31322269 |
2019 |