|
Severe myopia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent linkage analysis of seven families with autosomal dominant high myopia has identified one locus (MYP2) for high myopia on chromosome 18p11.31 (Young et al.: Am J Hum Genet 1998;63:109-119).
|
11449316 |
2001 |
|
Severe myopia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A genomic interval of 2.2 centiMorgans (cM) was defined on chromosome band 18p11.31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus.
|
15723005 |
2005 |
|
Myopia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The most common macular disorders were an epiretinal membrane (n = 130), myopia atrophy (n = 61) and a dome-shaped macular with pathologic myopia (n = 32).
|
29572456 |
2018 |
|
Staphyloma posticum
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Preoperative OCT examination resulted in the exclusion of 8 eyes in 4 patients with bilateral posterior staphyloma diagnosing unexpected staphylomatous macular patterns in 2 patients with RP and no sign of pathologic myopia.
|
28009400 |
2017 |
|
Age related macular degeneration
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Particularly, age-related macular degeneration (AMD) and pathologic myopia (PM) are the most frequent diseases related to CNV development.
|
20887247 |
2011 |
|
Blindness
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy.4 In this video, the authors describe their technique of using a subretinal injection of recombinant tissue plasminogen activator with a concurrent gas tamponade to displace SMH.
|
30998250 |
2019 |
|
Blindness
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
The burden of myopia is tremendous, as adults with HM are more likely to develop pathologic myopia (PM) changes that can lead to blindness.
|
30707221 |
2019 |
|
Myopic choroidal neovascularization
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Diagnosis and treatment guideline for myopic choroidal neovascularization due to pathologic myopia.
|
29111299 |
2018 |
|
Myopic choroidal neovascularization
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Real-world data on ranibizumab for myopic choroidal neovascularization due to pathologic myopia: results from a post-marketing surveillance in Japan.
|
30158574 |
2018 |
|
Retinitis Pigmentosa
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Identification of novel X-linked gain-of-function RPGR-ORF15 mutation in Italian family with retinitis pigmentosa and pathologic myopia.
|
27995965 |
2016 |
|
Exudative age-related macular degeneration
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Choroidal neovascularization (CNV) in adults is most commonly associated with neovascular age-related macular degeneration (AMD) and pathologic myopia.
|
30727875 |
2018 |
|
Unspecified visual loss
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy.4 In this video, the authors describe their technique of using a subretinal injection of recombinant tissue plasminogen activator with a concurrent gas tamponade to displace SMH.
|
30998250 |
2019 |
|
Chorioretinal atrophy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Lacquer cracks detected in rge chicks subsequently progressed to patchy chorioretinal atrophy, which is also commonly seen in patients with pathologic myopia.
|
30586351 |
2019 |
|
Retinal Detachment
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Amniotic membrane for retinal detachment due to paravascular retinal breaks over patchy chorioretinal atrophy in pathologic myopia.
|
31766876 |
2020 |
|
Retinal Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Myopic retinopathy was defined according to the Pathologic Myopia Study Group.
|
27860316 |
2017 |
|
Central retinal vein occlusion
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Aqueous humour from eyes with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), diabetic macular oedema (DME), neovascular age-related macular degeneration (nAMD) or pathologic myopia associated choroidal neovascularization (pmCNV) was sampled prior to 1st (n = 144) and 2nd (n = 48) intravitreal anti-VEGF therapy.
|
31531945 |
2019 |
|
Choroidal retinal neovascularization
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy.4 In this video, the authors describe their technique of using a subretinal injection of recombinant tissue plasminogen activator with a concurrent gas tamponade to displace SMH.
|
30998250 |
2019 |
|
Venous retinal branch occlusion
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Aqueous humour from eyes with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), diabetic macular oedema (DME), neovascular age-related macular degeneration (nAMD) or pathologic myopia associated choroidal neovascularization (pmCNV) was sampled prior to 1st (n = 144) and 2nd (n = 48) intravitreal anti-VEGF therapy.
|
31531945 |
2019 |
|
Epiretinal Membrane
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The most common macular disorders were an epiretinal membrane (n = 130), myopia atrophy (n = 61) and a dome-shaped macular with pathologic myopia (n = 32).
|
29572456 |
2018 |
|
Myopic macular degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We carried out a literature review (September 2015) of all English-language articles in PubMed resulting from searches of the following terms: "choroidal neovascularization" AND "myopia" OR "myopic macular degeneration" OR "degenerative myopia" OR "myopic maculopathy" OR "myopic retinopathy" OR "pathological myopia" OR "pathologic myopia."
|
28655539 |
2017 |
|
Diabetic macular edema
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Aqueous humour from eyes with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), diabetic macular oedema (DME), neovascular age-related macular degeneration (nAMD) or pathologic myopia associated choroidal neovascularization (pmCNV) was sampled prior to 1st (n = 144) and 2nd (n = 48) intravitreal anti-VEGF therapy.
|
31531945 |
2019 |
|
Punctate inner choroidopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The etiologies were idiopathic CNV (ICNV, 43.9%), pathologic myopia (PM, 21.9%), punctate inner choroidopathy (PIC, 17.4%), polypoidal choroidal vasculopathy (4.4%), multifocal choroiditis with panuveitis (3.6%), and other disorders (8.8%).
|
30153680 |
2019 |
|
Choroidal neovascular membrane (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy.4 In this video, the authors describe their technique of using a subretinal injection of recombinant tissue plasminogen activator with a concurrent gas tamponade to displace SMH.
|
30998250 |
2019 |
|
Multifocal choroiditis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The etiologies were idiopathic CNV (ICNV, 43.9%), pathologic myopia (PM, 21.9%), punctate inner choroidopathy (PIC, 17.4%), polypoidal choroidal vasculopathy (4.4%), multifocal choroiditis with panuveitis (3.6%), and other disorders (8.8%).
|
30153680 |
2019 |
|
MYOPIA 2 (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes.
|
15723005 |
2005 |