|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current consensus threshold value for high myopia is a spherical equivalent refractive error ≤ -6.00 D. "Pathologic myopia" is proposed as the categorical term for the adverse, structural complications of myopia.
|
30817826 |
2019 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the terms high myopia and pathologic myopia are often used interchangeably, they do not refer to the same eye disease.
|
30391362 |
2019 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
High myopia may develop to pathologic myopia, which brings severe visual impairment; however, the etiology is not fully understood.
|
31547036 |
2019 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approaches to prevent myopia-related blindness should therefore attempt to prevent or delay the onset of myopia among children by increased outdoor time; retard progression from low/mild myopia to HM, through optical (e.g., defocus incorporated soft contact lens, orthokeratology, and progressive-additional lenses) and pharmacological (e.g., low dose of atropine) interventions; and/or retard progression from HM to PM through medical/surgical treatments (e.g., anti-VEGF therapies, macula buckling, and scleral crosslinking).
|
30707221 |
2019 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among all the patients with different types of refractive errors, myopia was found in 47.4%, high myopia in 6.8% and pathologic myopia in 2.2%.
|
30209314 |
2018 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
High myopia and pathologic myopia are common causes of visual morbidity.
|
30030628 |
2018 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These approaches should enable the current epidemics of myopia and high myopia to be turned around, preventing an explosion of pathologic myopia.
|
27617538 |
2017 |
|
Severe myopia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A genomic interval of 2.2 centiMorgans (cM) was defined on chromosome band 18p11.31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus.
|
15723005 |
2005 |
|
Severe myopia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to determine whether DNA sequence variants in the human TGIF gene are causally related to MYP2-associated high myopia.
|
15223781 |
2004 |
|
Severe myopia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent linkage analysis of seven families with autosomal dominant high myopia has identified one locus (MYP2) for high myopia on chromosome 18p11.31 (Young et al.: Am J Hum Genet 1998;63:109-119).
|
11449316 |
2001 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Approaches to prevent myopia-related blindness should therefore attempt to prevent or delay the onset of myopia among children by increased outdoor time; retard progression from low/mild myopia to HM, through optical (e.g., defocus incorporated soft contact lens, orthokeratology, and progressive-additional lenses) and pharmacological (e.g., low dose of atropine) interventions; and/or retard progression from HM to PM through medical/surgical treatments (e.g., anti-VEGF therapies, macula buckling, and scleral crosslinking).
|
30707221 |
2019 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Myopia is a highly frequent ocular disorder worldwide and pathologic myopia is the 4th most common cause of irreversible blindness in developed countries.
|
30391362 |
2019 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
The current consensus threshold value for high myopia is a spherical equivalent refractive error ≤ -6.00 D. "Pathologic myopia" is proposed as the categorical term for the adverse, structural complications of myopia.
|
30817826 |
2019 |
|
Myopia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The most common macular disorders were an epiretinal membrane (n = 130), myopia atrophy (n = 61) and a dome-shaped macular with pathologic myopia (n = 32).
|
29572456 |
2018 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Within the pathologic myopia (PM) group (n = 521 eyes), progression of myopic maculopathy was associated with female gender (odds ratio [OR], 2.21; P = 0.001), older age (OR, 1.03; P = 0.002), longer axial length (OR, 1.20; P = 0.007), greater axial elongation (OR, 1.45; P = 0.005), and development of parapapillary atrophy (PPA; OR, 3.14; P < 0.001).
|
29371011 |
2018 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
There still seems to be no generally accepted classification of myopia and particularly not of degenerative or pathologic myopia.
|
29437569 |
2018 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Pathologic myopia described as myopia accompanied by severe deformation of the eye besides excessive elongation of eye, is usually a genetic heterogeneous disorder characterized by extreme, familial, early-onset vision loss.
|
28837730 |
2017 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Pathologic myopia (PM), a possible consequence of myopia, is estimated to affect up to 3% of the global population.
|
28655539 |
2017 |
|
Myopia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Similarly, the presence of myopic fundus lesions in addition to a high degree of myopia has been used to define pathologic myopia; however, such lesions often develop with age and they are not characteristic of pathologic myopia.
|
27755375 |
2017 |
|
Staphyloma posticum
|
0.040 |
Biomarker
|
disease |
BEFREE |
Posterior staphyloma in pathologic myopia.
|
30537538 |
2019 |
|
Staphyloma posticum
|
0.040 |
Biomarker
|
disease |
BEFREE |
The presence of posterior staphyloma, which is the most common finding in patients with pathologic myopia, is the key differentiating factor between high and pathologic myopia.
|
30391362 |
2019 |
|
Blindness
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy.4 In this video, the authors describe their technique of using a subretinal injection of recombinant tissue plasminogen activator with a concurrent gas tamponade to displace SMH.
|
30998250 |
2019 |
|
Blindness
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Ocular alterations associated with pathologic myopia, especially those involving the macular area-defined as myopic maculopathy-are the leading causes of vision loss in patients with pathologic myopia.
|
30391362 |
2019 |
|
Blindness
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
The burden of myopia is tremendous, as adults with HM are more likely to develop pathologic myopia (PM) changes that can lead to blindness.
|
30707221 |
2019 |
|
Disorder of macula of retina
|
0.040 |
Biomarker
|
group |
BEFREE |
Myopic maculopathy was defined according to the criteria of the Meta-analysis of Pathologic Myopia Study Group classification system.
|
31260519 |
2019 |