|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of Max binding protein as a novel binding protein of Nck1 and characterization of its role in inhibiting human liver cancer SK-HEP-1 cells.
|
22964333 |
2012 |
|
Albuminuria
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Nck proteins maintain the adult glomerular filtration barrier.
|
19443634 |
2009 |
|
Aristolochic Acid Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings show that AA inhibits Slit2-induced migration and tube formation via inactivation of Robo1/Robo2-NCK1/NCK2 signaling pathway in HUVECs, and NCK1 might be a potential agent for vascular remodeling in AAN and diseases associated with impaired angiogenesis.
|
30381256 |
2019 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we have determined prognostic importance of Nck1 protein in astrocytoma progression.
|
30146921 |
2019 |
|
Blood urea nitrogen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic studies of body mass index yield new insights for obesity biology.
|
25673413 |
2015 |
|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
|
31761329 |
2020 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that the association between TF C alleles and lung cancer may be secondary and dependent on linkage disequilibrium with allelic variants of newly discovered tumor-associated genes known to map to the same position (3q21) as TF, e.g.NCK and H-RYK.
|
10343198 |
1999 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer.
|
29218693 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
As for mechanistic investigation, starBase (http://starbase.sysu.edu.cn/) suggested that NCK1-AS1 expression in OC tissues was significantly positively correlated with its adjacent gene, NCK adaptor protein 1 (NCK1).
|
31761329 |
2020 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
After confirmation by RT-PCR, Western blotting and immunohistochemistry, we found that B-FABP, NCK-1, and CDK4 were related to the pathogenesis of cervical cancer.
|
23255846 |
2012 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
Cervical high grade squamous intraepithelial lesion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
After confirmation by RT-PCR, Western blotting and immunohistochemistry, we found that B-FABP, NCK-1, and CDK4 were related to the pathogenesis of cervical cancer.
|
23255846 |
2012 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
Childhood Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we have determined prognostic importance of Nck1 protein in astrocytoma progression.
|
30146921 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
|
28112199 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By gene expression analyses, we revealed a high co-overexpression of STAT3 and NCK1 in CRC tissues.
|
28455144 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, we found that stable depletion of Nck1 in β cells promotes PERK activation and signaling, increases insulin biosynthesis, and improves cell viability in response to diabetes-related stresses.
|
29941454 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Accordingly, we found that stable depletion of Nck1 in β cells promotes PERK activation and signaling, increases insulin biosynthesis, and improves cell viability in response to diabetes-related stresses.
|
29941454 |
2018 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
This finding implicates an important role for glomerular NCK1 in DN pathogenesis under hyperglycemia.
|
23441190 |
2013 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |