|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
After confirmation by RT-PCR, Western blotting and immunohistochemistry, we found that B-FABP, NCK-1, and CDK4 were related to the pathogenesis of cervical cancer.
|
23255846 |
2012 |
|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
After confirmation by RT-PCR, Western blotting and immunohistochemistry, we found that B-FABP, NCK-1, and CDK4 were related to the pathogenesis of cervical cancer.
|
23255846 |
2012 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
ovarian neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
As for mechanistic investigation, starBase (http://starbase.sysu.edu.cn/) suggested that NCK1-AS1 expression in OC tissues was significantly positively correlated with its adjacent gene, NCK adaptor protein 1 (NCK1).
|
31761329 |
2020 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer.
|
29218693 |
2018 |
|
Malignant neoplasm of ovary
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
As for mechanistic investigation, starBase (http://starbase.sysu.edu.cn/) suggested that NCK1-AS1 expression in OC tissues was significantly positively correlated with its adjacent gene, NCK adaptor protein 1 (NCK1).
|
31761329 |
2020 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer.
|
29218693 |
2018 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We previously observed that MNT was differentially expressed in hepatocellular carcinoma (HCC) and interacted with Nck1 by 2-DE.
|
22244890 |
2012 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We previously identified a group of Nck Src homology 2 (SH2) domain‑binding proteins by combining the GST-Nck1-SH2 pull-down method with two-dimensional electrophoresis (2‑DE) in hepatocellular carcinoma (HCC) tissues.
|
23426619 |
2013 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
After confirmation by RT-PCR, Western blotting and immunohistochemistry, we found that B-FABP, NCK-1, and CDK4 were related to the pathogenesis of cervical cancer.
|
23255846 |
2012 |
|
cervical cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer.
|
29218693 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
As for mechanistic investigation, starBase (http://starbase.sysu.edu.cn/) suggested that NCK1-AS1 expression in OC tissues was significantly positively correlated with its adjacent gene, NCK adaptor protein 1 (NCK1).
|
31761329 |
2020 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we have determined prognostic importance of Nck1 protein in astrocytoma progression.
|
30146921 |
2019 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway.
|
30442385 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By gene expression analyses, we revealed a high co-overexpression of STAT3 and NCK1 in CRC tissues.
|
28455144 |
2017 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, we found that stable depletion of Nck1 in β cells promotes PERK activation and signaling, increases insulin biosynthesis, and improves cell viability in response to diabetes-related stresses.
|
29941454 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Accordingly, we found that stable depletion of Nck1 in β cells promotes PERK activation and signaling, increases insulin biosynthesis, and improves cell viability in response to diabetes-related stresses.
|
29941454 |
2018 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
This finding implicates an important role for glomerular NCK1 in DN pathogenesis under hyperglycemia.
|
23441190 |
2013 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This finding implicates an important role for glomerular NCK1 in DN pathogenesis under hyperglycemia.
|
23441190 |
2013 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Gain-of-function and loss-of-function studies have shown that ectopic expression of NCK1 enhanced metastasis and angiogenesis in CRC cells.
|
28455144 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
NCK1 was also significantly associated with serosal invasion, lymph metastasis, and tumor-node-metastasis classification but was inversely correlated with differentiation.
|
28455144 |
2017 |