|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
|
31761329 |
2020 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we have determined prognostic importance of Nck1 protein in astrocytoma progression.
|
30146921 |
2019 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway.
|
30442385 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown.
|
31807161 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Cervical high grade squamous intraepithelial lesion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD.
|
30442385 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further seen the prognostic significance of Nck1 in 246 glioblastoma tissue samples as visible from the TCGA database.
|
30146921 |
2019 |
|
Aristolochic Acid Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings show that AA inhibits Slit2-induced migration and tube formation via inactivation of Robo1/Robo2-NCK1/NCK2 signaling pathway in HUVECs, and NCK1 might be a potential agent for vascular remodeling in AAN and diseases associated with impaired angiogenesis.
|
30381256 |
2019 |
|
Childhood Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we have determined prognostic importance of Nck1 protein in astrocytoma progression.
|
30146921 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, we found that stable depletion of Nck1 in β cells promotes PERK activation and signaling, increases insulin biosynthesis, and improves cell viability in response to diabetes-related stresses.
|
29941454 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Accordingly, we found that stable depletion of Nck1 in β cells promotes PERK activation and signaling, increases insulin biosynthesis, and improves cell viability in response to diabetes-related stresses.
|
29941454 |
2018 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Loss of Nck1 and Nck2 in mural cells prevents NVT formation and vascular leakage and promotes revascularization, suggesting PDGFRβ-Y1009/NCK signaling as a potential target for the treatment of retinopathies.
|
30150707 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By gene expression analyses, we revealed a high co-overexpression of STAT3 and NCK1 in CRC tissues.
|
28455144 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Gain-of-function and loss-of-function studies have shown that ectopic expression of NCK1 enhanced metastasis and angiogenesis in CRC cells.
|
28455144 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
NCK1 was also significantly associated with serosal invasion, lymph metastasis, and tumor-node-metastasis classification but was inversely correlated with differentiation.
|
28455144 |
2017 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest that TNK2, WASP, and NCK1 may play important roles in mammalian virus infection.
|
28874467 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
|
28455144 |
2017 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
This finding implicates an important role for glomerular NCK1 in DN pathogenesis under hyperglycemia.
|
23441190 |
2013 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This finding implicates an important role for glomerular NCK1 in DN pathogenesis under hyperglycemia.
|
23441190 |
2013 |