|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
The tumor metastasis suppressor gene Drg-1 has been shown to suppress metastasis without affecting tumorigenicity in immunodeficient mouse models of prostate and colon cancer.
|
17178897 |
2006 |
|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |
|
Malignant tumor of colon
|
0.150 |
AlteredExpression
|
disease |
BEFREE |
The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
|
15520163 |
2004 |
|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drg1 may provide a new means to increase the sensitivity of colon cancer cells to CPT-11.
|
12124325 |
2002 |
|
Colon Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
|
15520163 |
2004 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |
|
Colon Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Drg1 mRNA has a length of approximately 3 kb and is induced approximately 20-fold during in vitro differentiation of the colon carcinoma cell lines HT29-D4 and Caco-2.
|
9251681 |
1997 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The tumor metastasis suppressor gene Drg-1 has been shown to suppress metastasis without affecting tumorigenicity in immunodeficient mouse models of prostate and colon cancer.
|
17178897 |
2006 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drg1 may provide a new means to increase the sensitivity of colon cancer cells to CPT-11.
|
12124325 |
2002 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells.
|
16707596 |
2006 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we explored the possibility that PTEN controls tumor metastasis by regulating the expression of the Drg-1 gene.
|
15520163 |
2004 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Our immunohistochemical analysis on prostate cancer specimens revealed that nuclear expression of ATF3 was inversely correlated to Drg-1 expression and positively correlated to metastases.
|
17178897 |
2006 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
N-myc downstream regulated gene 1 (NDRG1), also known as Cap43, Drg-1, and rit42, is expressed in various normal tissues and cancers, in which it is often associated with a favorable prognosis.
|
21784644 |
2011 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry.
|
12702552 |
2003 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Expression of Drg-1 has also been found to have a significant inverse correlation with metastasis or invasiveness in various types of human cancer.
|
17178897 |
2006 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
CD44s is decreased in both PIN and cancer; Drg-1, E-cadherin, KAI-1, RKIP, and SSeCKS show similar expression between benign epithelia and PIN, but are downregulated in invasive cancer; whereas, maspin, MKK4, Nm23 and PTEN are upregulated in PIN and downregulated in cancer.
|
22886631 |
2012 |
|
Secondary Neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In this study, we explored the possibility that PTEN controls tumor metastasis by regulating the expression of the Drg-1 gene.
|
15520163 |
2004 |
|
Secondary Neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Our immunohistochemical analysis on prostate cancer specimens revealed that nuclear expression of ATF3 was inversely correlated to Drg-1 expression and positively correlated to metastases.
|
17178897 |
2006 |
|
Secondary Neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |
|
Secondary Neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Together, our results strongly suggest functional involvement of the Drg-1 gene in suppressing the metastatic advancement of human breast cancer.
|
15184886 |
2004 |