|
Colon Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Drg1 mRNA has a length of approximately 3 kb and is induced approximately 20-fold during in vitro differentiation of the colon carcinoma cell lines HT29-D4 and Caco-2.
|
9251681 |
1997 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The absence of Drg1 induction in growth-inhibited A431 epidermoid carcinoma cells indicates that Drg1 up-regulation in colon carcinoma cells is not a result of decreased proliferation.
|
9251681 |
1997 |
|
ADENOMAS AND ADENOCARCINOMAS
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Compared to normal colon mucosa, Drg1 mRNA expression is decreased in colon adenomas and adenocarcinomas.
|
9251681 |
1997 |
|
Prostatic Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
One of the genes markedly upregulated by androgens proved to be identical to differentiation-related gene 1 (Drg1; also described as RTP, Cap43 and rit42), a gene whose expression has recently been shown to be diminished in colon, breast and prostate tumors.
|
10428464 |
1999 |
|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We propose that Drg-1 suppresses colon cancer metastasis by inducing colon cancer cell differentiation and partially reversing the metastatic phenotype.
|
10676663 |
2000 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Functional studies revealed that overexpression of Drg-1 in metastatic colon cancer cells reduced in vitro invasion through Matrigel and suppressed in vivo liver metastases in nude mice.
|
10676663 |
2000 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Functional studies revealed that overexpression of Drg-1 in metastatic colon cancer cells reduced in vitro invasion through Matrigel and suppressed in vivo liver metastases in nude mice.
|
10676663 |
2000 |
|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drg1 may provide a new means to increase the sensitivity of colon cancer cells to CPT-11.
|
12124325 |
2002 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drg1 may provide a new means to increase the sensitivity of colon cancer cells to CPT-11.
|
12124325 |
2002 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Similarly, tumors established from Drg1 overexpressing SW620 cells were more resistant to CPT-11 as compared with tumors established from vector-transfected SW620 cells in mice.
|
12124325 |
2002 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry.
|
12702552 |
2003 |
|
Secondary Neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Recently, Drg-1 has also been shown to be involved in tumor progression in animals, although the clinical significance of its involvement remains to be investigated.
|
12702552 |
2003 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry.
|
12702552 |
2003 |
|
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry.
|
12702552 |
2003 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
To clarify the functional role of Drg-1 in prostate cancer, we examined a clinical archive of cancer specimens for the expression of Drg-1 by immunohistochemistry.
|
12702552 |
2003 |
|
Prostatic Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |
|
Malignant tumor of colon
|
0.150 |
Biomarker
|
disease |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Malignant tumor of colon
|
0.150 |
AlteredExpression
|
disease |
BEFREE |
The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
|
15520163 |
2004 |
|
Colon Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The Drg-1 gene has been shown to suppress tumor metastasis in animal models of prostate and colon cancer, and the expression of this gene is significantly reduced with advancement of prostate and breast cancers in clinical setting.
|
15520163 |
2004 |
|
Colon Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we explored the possibility that PTEN controls tumor metastasis by regulating the expression of the Drg-1 gene.
|
15520163 |
2004 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |