NEDD4, NEDD4 E3 ubiquitin protein ligase, 4734

N. diseases: 101; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.350 GeneticVariation disease UNIPROT
CUI: C0221043
Disease: Liddle Syndrome
Liddle Syndrome 		0.040 Biomarker disease BEFREE WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. 8665844 1996
CUI: C0221043
Disease: Liddle Syndrome
Liddle Syndrome 		0.040 GeneticVariation disease BEFREE This process may be at least partially impaired in Liddle's syndrome due to reduced Nedd4 binding, leading to increased retention of ENaC at the cell surface. 10720933 2000
CUI: C0221043
Disease: Liddle Syndrome
Liddle Syndrome 		0.040 Biomarker disease BEFREE Liddle's syndrome: a novel mouse Nedd4 isoform regulates the activity of the epithelial Na(+) channel. 11473628 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease BEFREE In searching for candidate genes for bipolar disorder on chromosome 18q21, a novel gene homologous to NEDD4 (Neural precursor cells expressed developmentally down-regulated) was identified using exon trapping and cDNA cloning. 11840194 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET In searching for candidate genes for bipolar disorder on chromosome 18q21, a novel gene homologous to NEDD4 (Neural precursor cells expressed developmentally down-regulated) was identified using exon trapping and cDNA cloning. 11840194 2001
CUI: C0221043
Disease: Liddle Syndrome
Liddle Syndrome 		0.040 GeneticVariation disease BEFREE Liddle's syndrome mutations disrupt the interaction between ENaC and Nedd4, resulting in an increase in the number of ENaC channels at the cell surface. 11943747 2002
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.030 AlteredExpression disease BEFREE PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 12907594 2003
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.030 AlteredExpression disease BEFREE PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 12907594 2003
CUI: C0268436
Disease: Pseudohypoaldosteronism, Type I
Pseudohypoaldosteronism, Type I 		0.010 GeneticVariation disease BEFREE Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. 15547682 2004
CUI: C0007959
Disease: Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease 		0.020 Biomarker disease BEFREE Thus the potential E3 ubiquitin ligase activity of SIMPLE, alteration in its interactions with NEDD4 or TSG101, or changes in its properties as a clathrin coat adaptor may underlie the pathogenesis of Charcot-Marie-Tooth disease. 15776429 2005
CUI: C0007959
Disease: Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease 		0.020 Biomarker disease BEFREE SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. 16118794 2005
CUI: C0270913
Disease: Charcot-Marie-Tooth disease, Type 1C
Charcot-Marie-Tooth disease, Type 1C 		0.010 GeneticVariation disease BEFREE We examine three CMT1C-associated SIMPLE mutations and show that they do not affect the interaction with NEDD4 or TSG101, nor do they lead to altered subcellular localization. 16118794 2005
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.300 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 Biomarker disease LHGDN Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation. 16867982 2006
CUI: C0282687
Disease: Hemorrhagic Fever, Ebola
Hemorrhagic Fever, Ebola 		0.030 Biomarker disease BEFREE Furthermore, overexpression of ISG15 diminished the ability of Nedd4 to ubiquitinate viral matrix proteins and led to a decrease in the release of Ebola VP40 virus-like particles from the cells. 18287095 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.010 AlteredExpression group LHGDN A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. 18703514 2008
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.010 AlteredExpression group LHGDN Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas. 19024597 2008
CUI: C0026846
Disease: Muscular Atrophy
Muscular Atrophy 		0.200 Biomarker phenotype RGD The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. 19125695 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE We show that this motif also binds Nedd4-related proteins and several other WW domain-containing proteins, including the tumor suppressor oxidoreductase Wwox. 19144635 2009
CUI: C0022548
Disease: Keloid
Keloid 		0.440 Biomarker disease CTD_human A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. 20711176 2010
CUI: C0022548
Disease: Keloid
Keloid 		0.440 GeneticVariation disease GWASDB A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. 20711176 2010
CUI: C0022548
Disease: Keloid
Keloid 		0.440 GeneticVariation disease GWASCAT A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. 20711176 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE In addition, manipulation of NEDD4-1 expression in different lung cell systems demonstrated that suppression of NEDD4-1 expression significantly reduced proliferation of NSCLC cells in vitro and tumor growth in vivo, whereas NEDD4-1 overexpression facilitated anchorage-dependent and independent growth in vitro of nontransformed lung epithelial cells that lack pRB and TP53 (BEAS-2B). 20889565 2010
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE NEDD4-1 overexpression also augmented the tumorigenicity of lung cancer cells that have an intact PTEN gene (NCI-H460 cells). 20889565 2010